Intrathecal prostaglandin E1 produces a long-lasting allodynic state
Intrathecal prostaglandin E1 produces a long-lasting allodynic state
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鞘内注射前列腺素 E1 产生持久的异常疼痛状态
DOI：
10.1016/0304-3959(95)00055-0
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发表时间：
1995
期刊：
影响因子：
7.4
通讯作者：
J. G. Collins
中科院分区：
文献类型：
--
作者：
Y. Saito;M. Kaneko;Y. Kirihara;Y. Kosaka;J. G. Collins
前列腺素(PG)受体在脊髓中的存在已被证实，但它们在感觉加工中的作用尚不清楚。前列腺素E_1在临床上被广泛用作血管扩张剂。本研究旨在探讨鞘内注射前列腺素E_1(PGE1)对伤害性躯体、伤害性内脏和非伤害性躯体刺激等不同类型感觉信息传递的影响。甩尾(Tf)试验用于测量对伤害性躯体刺激的反应，结直肠扩张试验用于检测对伤害性内脏刺激的反应。测量Semmes-Weinstein单丝(SWMS)对机械压力的收缩反应，以评估其对非伤害性机械躯体刺激的敏感性。鞘内注射PGE1 10 0 ng或5 0 0 ng后，TF潜伏期和结直肠扩张阈值在短时间内(10~2 0min)降低。与此形成鲜明对比的是，给予0.217、0.745和2.35g 3种不同强度的前列腺素E 1后，激越评分(痛觉异常)显著增加。当PGE1经it导管或直接it穿刺法给药时，激越评分增加，且这种增加持续到给药后至少2天。然而，鞘内注射生理盐水并没有对SWMS产生的TF潜伏期、结直肠扩张阈值或激越评分产生任何改变。给药后48h，给予500ngPGE1和生理盐水的大鼠脊髓组织学差异无统计学意义。这些结果表明，PGE1可能在脊髓水平的感觉加工通路中触发一种超敏(痛觉超敏和/或痛觉过敏)状态。它们还表明，在PGE1的直接作用消失后，PGE1产生的无害但不有害的信息的加工过程继续发生长期的变化。
The existence of prostaglandin (PG) receptors in the spinal cord has been demonstrated, but their role in sensory processing is not yet well defined. PGE 1 is widely used clinically as a vasodilator. The present study was designed to investigate the effects of intrathecally administered PGE 1 on the transmission of different types of sensory information, including that associated with noxious somatic, noxious visceral, and non-noxious somatic stimulation. The tail-flick (TF) test was employed to measure responses to noxious somatic stimuli, and the colorectal distension test was used to examine responses to noxious visceral stimuli. Withdrawal response to mechanical pressure produced by Semmes-Weinstein mono-filaments (SWMs) was measured as an assessment of sensitivity to non-noxious mechanical somatic stimulation. TF latencies and colorectal distension thresholds decreased for a short time (10–20 min) following the intrathecal (it) administration of both 100 ng or 500 ng of PGE 1. In sharp contrast to these short duration effects, there was a long-lasting increase in agitation scores (allodynia) produced by 3 different intensities of SWMs (0.217, 0.745 and 2.35 g) after administration of PGE 1. The changes in agitation scores to SWMs were dependent on the dose of PGE 1 and the intensity of stimulation. This increase of agitation score was seen when PGE 1 was administered through the it catheter or by direct it puncture and the increase lasted for at least 2 days after drug administration. Intrathecal administration of saline, however, did not produce any changes in TF latencies, colorectal distension thresholds, or agitation scores produced by SWMs. No significant histological difference was seen between spinal cords exposed to 500 ng PGE 1 and saline 48 h after drug administration. These results demonstrate that PGE 1 may trigger a hypersensitive (allodynic and/or hyperalgesic) state in sensory processing pathways at the spinal level. They also indicate that long-lasting changes in processing of non-noxious, but not noxious, information produced by PGE 1 continues after the disappearance of the direct action of PGE 1.
高剂量鞘内吗啡引起的大鼠异常性疼痛的药理学。
DOI：
--
发表时间：
1988
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Yaksh,TL;Harty,GJ
通讯作者：
Harty,GJ
影响因子：
2.9
作者：
Hossaini, Mehdi;French, Pim J.;Holstege, Jan C.
通讯作者：
Holstege, Jan C.
影响因子：
56.9
作者：
MALMBERG, AB;YAKSH, TL
通讯作者：
YAKSH, TL