Human medullary responses to cooling and rewarming the skin: a functional MRI study.
Human medullary responses to cooling and rewarming the skin: a functional MRI study.
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人类髓质对皮肤冷却和复温的反应：功能性 MRI 研究。
DOI：
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发表时间：
2006
影响因子：
11.1
通讯作者：
G. Egan
中科院分区：
文献类型：
--
作者：
R. McAllen;Michael Farrell;John M. Johnson;D. Trevaks;Leonie J. Cole;M. McKinley;G. Jackson;D. Denton;G. Egan
皮肤温度的下降会引起一系列体温调节反应，从而降低核心温度下降的可能性。动物研究表明，延髓中缝神经元是必不可少的冷防御，介导皮肤血管收缩和产热反应的环境冷却;然而，中缝神经元参与人体体温调节尚未调查。本研究使用功能性MRI与解剖学引导的感兴趣区域（ROI）的方法来表征的变化，在人体髓质的9个正常受试者的血液中的氧水平依赖（BOLD）的信号在无毒冷却和复温的皮肤由水灌注的身体西装。在脑桥尾侧延髓腹侧中线（头端延髓缝）上覆盖4.9 +/- 0.3 mm（2）的ROI显示，与其他时间相比，皮肤冷却期间BOLD信号增加3.9%（P < 0.01）。总体而言，该信号显示出与皮肤温度的强负相关性（R = 0.48，P < 0.001）。在相同水平（面积，126 +/- 15 mm（2）），覆盖内部髓横截面的较大ROI显示平均BOLD信号随冷却无显著变化（+0.2%，P > 0.05）。这些研究结果表明，人类吻端延髓中缝核神经元选择性激活，以响应温度调节的挑战，并指出在啮齿类动物的中缝苍白核同源的温度调节神经元的位置。
A fall in skin temperature precipitates a repertoire of thermoregulatory responses that reduce the likelihood of a decrease in core temperature. Studies in animals suggest that medullary raphé neurons are essential for cold-defense, mediating both the cutaneous vasoconstrictor and thermogenic responses to ambient cooling; however, the involvement of raphé neurons in human thermoregulation has not been investigated. This study used functional MRI with an anatomically guided region of interest (ROI) approach to characterize changes in the blood oxygen level-dependent (BOLD) signal within the human medulla of nine normal subjects during non-noxious cooling and rewarming of the skin by a water-perfused body suit. An ROI covering 4.9 +/- 0.3 mm(2) in the ventral midline of the medulla immediately caudal to the pons (the rostral medullary raphé) showed an increase in BOLD signal of 3.9% (P < 0.01) during periods of skin cooling, compared with other times. Overall, that signal showed a strong inverse correlation (R = 0.48, P < 0.001) with skin temperature. A larger ROI covering the internal medullary cross section at the same level (area, 126 +/- 15 mm(2)) showed no significant change in mean BOLD signal with cooling (+0.2%, P > 0.05). These findings demonstrate that human rostral medullary raphé neurons are selectively activated in response to a thermoregulatory challenge and point to the location of thermoregulatory neurons homologous to those of the raphé pallidus nucleus in rodents.
影响因子：
5.5
作者：
KREGEL, KC;SEALS, DR;CALLISTER, R
通讯作者：
CALLISTER, R
DOI：
10.1073/pnas.0409753102
发表时间：
2005-04-05
影响因子：
11.1
作者：
Egan, GF;Johnson, J;Fox, PT
通讯作者：
Fox, PT