The Drosophila melanogaster circadian pacemaker circuit

The Drosophila melanogaster circadian pacemaker circuit
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果蝇昼夜节律起搏器电路

DOI:
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发表时间:
2008
期刊:
Journal Genetika
影响因子:
--
通讯作者:
V. Sheeba
V. Sheeba
中科院分区:
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文献类型:
--
作者:
V. Sheeba

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作为一个实验模型系统,果蝇黑腹果蝇在塑造我们对生物钟的理解方面起到了开创性的作用。在过去的四十年里,我们掌握的丰富的遗传工具使我们能够发现昼夜节律的遗传和分子基础。最近,对组成昼夜节律机制的各种神经元亚群的解剖学、神经化学和电生理特性的详细研究揭示了这些神经元聚集在一起充当神经元回路的途径。因此,黑腹大鼠昼夜节律起搏电路为研究神经元电路及其功能提供了一个相对简单和有吸引力的模型。
As an experimental model system, the fruit fly Drosophila melanogaster has been seminal in shaping our understanding of the circadian clockwork. The wealth of genetic tools at our disposal over the past four decades has enabled discovery of the genetic and molecular bases of circadian rhythmicity. More recently, detailed investigation leading to the anatomical, neuro-chemical and electrophysiological characterization of the various neuronal subgroups that comprise the circadian machinery has revealed pathways through which these neurons come together to act as a neuronal circuit. Thus the D. melanogaster circadian pacemaker circuit presents a relatively simple and attractive model for the study of neuronal circuits and their functions.
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