Histone Deacetylase 7-Derived Peptides Play a Vital Role in Vascular Repair and Regeneration.
Histone Deacetylase 7-Derived Peptides Play a Vital Role in Vascular Repair and Regeneration.
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组蛋白脱乙酰酶 7 衍生肽在血管修复和再生中发挥重要作用
DOI：
10.1002/advs.201800006
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Zhao Q
中科院分区：
文献类型：
--
作者：
Pan Y;Yang J;Wei Y;Wang H;Jiao R;Moraga A;Zhang Z;Hu Y;Kong D;Xu Q;Zeng L;Zhao Q
Cardiovascular disease is a leading cause of morbidity and mortality globally. Accumulating evidence indicates that local resident stem/progenitor cells play an important role in vascular regeneration. Recently, it is demonstrated that a histone deacetylase 7‐derived 7‐amino acid peptide (7A, MHSPGAD) is critical in modulating the mobilization and orientated differentiation of these stem/progenitor cells. Here, its therapeutic efficacy in vascular repair and regeneration is evaluated. In vitro functional analyses reveal that the 7A peptide, in particular phosphorylated 7A (7Ap, MH[pSer]PGAD), could increase stem cell antigen‐1 positive (Sca1+) vascular progenitor cell (VPC) migration and differentiation toward an endothelial cell lineage. Furthermore, local delivery of 7A as well as 7Ap could enhance angiogenesis and ameliorate vascular injury in ischaemic tissues; these findings are confirmed in a femoral artery injury model and a hindlimb ischaemia model, respectively. Importantly, sustained delivery of 7A, especially 7Ap, from tissue‐engineered vascular grafts could attract Sca1+‐VPC cells into the grafts, contributing to endothelialization and intima/media formation in the vascular graft. These results suggest that this novel type of peptides has great translational potential in vascular regenerative medicine.
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影响因子：
3.4
作者：
Psaltis, Peter J.;Harbuzariu, Adriana;Delacroix, Sinny;Holroyd, Eric W.;Simari, Robert D.
通讯作者：
Simari, Robert D.
影响因子：
37.8
作者：
Pektok, Erman;Nottelet, Benjamin;Walpoth, Beat H.
通讯作者：
Walpoth, Beat H.
影响因子：
20.1
作者：
Margariti, Andriana;Zampetaki, Anna;Zeng, Lingfang
通讯作者：
Zeng, Lingfang
DOI：
10.1073/pnas.0803873105
发表时间：
2008-09-23
影响因子：
11.1
作者：
Silva, Eduardo A.;Kim, Eun-Suk;Mooney, David J.
通讯作者：
Mooney, David J.
影响因子：
64.5
作者：
Chang, Shurong;Young, Bryan D.;Olson, Eric N.
通讯作者：
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