Interferon regulatory factor 4 and 8 in B-cell development.

Interferon regulatory factor 4 and 8 in B-cell development.
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DOI:
10.1016/j.it.2008.07.006
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发表时间:
2008-10
影响因子:
16.8
通讯作者:
Lu R
Lu R
中科院分区:
医学1区
文献类型:
--
作者:
Lu R

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IRF4和IRF8是干扰素调节因子家族转录因子的成员,对T细胞、巨噬细胞和树突状细胞的发育和功能是必不可少的。最近的一系列研究进一步证实了IRF4和IRF8在B细胞发育的几个阶段中的关键作用,包括前B细胞发育、受体编辑、生发中心反应和浆细胞生成。总的来说,这些新的研究提供了对IRF4和8功能的分子洞察力,并强调了在B细胞发育过程中对IRF4和8的要求。本文就IRF4和IRF8在B细胞发育中作用的最新研究进展作一综述。
IRF4 and 8 are members of the interferon regulatory factor family of transcription factors and have been shown to be essential for the development and function of T cells, macrophages and dendritic cells. A series of recent studies have further demonstrated critical functions for IRF4 and 8 at several stages of B cell development including pre-B cell development, receptor editing, germinal center reaction and plasma cell generation. Collectively, these new studies provide molecular insights into the function of IRF4 and 8 and underscore a requirement for IRF4 and 8 throughout B cell development. This review focuses on the recent advances on roles of IRF4 and 8 in B cell development.
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