Mesenchymal stem cell secretome and regenerative therapy after cancer.
Mesenchymal stem cell secretome and regenerative therapy after cancer.
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DOI：
10.1016/j.biochi.2013.05.010
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发表时间：
2013-12
期刊：
影响因子：
3.9
通讯作者：
Donnenberg, Albert D.
中科院分区：
文献类型：
--
作者：
Zimmerlin, Ludovic;Park, Tea Soon;Zambidis, Elias T.;Donnenberg, Vera S.;Donnenberg, Albert D.
关键词：
癌症治疗通常依赖于肿瘤消融技术，这可能导致主要的功能缺陷或毁容缺陷。这些治疗后损伤需要在癌症缓解期间开发安全的再生治疗策略。许多当前的组织修复方法利用间充质干细胞/基质细胞（MSC）的旁分泌（免疫调节、促血管生成、抗凋亡和促存活作用）或恢复（功能或结构组织修复）性质。然而，在癌症缓解期间应用再生疗法的主要问题仍然是可能引发癌症复发。肿瘤复发意味着罕见的肿瘤起始癌细胞亚群的持续存在，这些细胞可以逃避抗癌治疗，并在特定的小生境中休眠，等待通过未知的刺激重新激活。成功的再生治疗所需的许多成分（血管重建、免疫抑制、细胞归巢、组织生长促进）对肿瘤进展和转移也至关重要。虽然已经在多种癌症中证明了致瘤细胞（特别是侵袭性癌细胞系）和MSC（包括肿瘤基质驻留群体）之间的双向串扰，但是用于再生目的的局部或全身MSC递送对缓解期间持续存在的癌细胞的影响仍然存在争议。文献中已经报道了MSC的促肿瘤发生和抗肿瘤发生作用。我们自己使用乳腺癌临床分离株的数据表明，休眠样肿瘤起始细胞不响应MSC信号，而不像活跃分裂的癌细胞那样受益于支持性MSC的存在。从各种组织分离的MSC的分泌组可以部分地发散，但它包括细胞因子（即CCL 2、CCL 5、IL-6、TGFβ、VEGF）的核心，其已经涉及肿瘤生长和/或转移。本文综述了已发表的研究MSC和癌细胞之间相互作用的模型，重点是MSC分泌组对癌细胞活性的影响，并讨论了癌症后再生治疗的意义。
Cancer treatment generally relies on tumor ablative techniques that can lead to major functional or disfiguring defects. These post-therapy impairments require the development of safe regenerative therapy strategies during cancer remission. Many current tissue repair approaches exploit paracrine (immunomodulatory, pro-angiogenic, anti-apoptotic and pro-survival effects) or restoring (functional or structural tissue repair) properties of mesenchymal stem/stromal cells (MSC). Yet, a major concern in the application of regenerative therapies during cancer remission remains the possible triggering of cancer recurrence. Tumor relapse implies the persistence of rare subsets of tumor-initiating cancer cells which can escape anti-cancer therapies and lie dormant in specific niches awaiting reactivation via unknown stimuli. Many of the components required for successful regenerative therapy (revascularization, immunosuppression, cellular homing, tissue growth promotion) are also critical for tumor progression and metastasis. While bidirectional crosstalk between tumorigenic cells (especially aggressive cancer cell lines) and MSC (including tumor stroma-resident populations) has been demonstrated in a variety of cancers, the effects of local or systemic MSC delivery for regenerative purposes on persisting cancer cells during remission remain controversial. Both pro- and anti-tumorigenic effects of MSC have been reported in the literature. Our own data using breast cancer clinical isolates have suggested that dormant-like tumor-initiating cells do not respond to MSC signals, unlike actively dividing cancer cells which benefited from the presence of supportive MSC. The secretome of MSC isolated from various tissues may partially diverge, but it includes a core of cytokines (i.e. CCL2, CCL5, IL-6, TGFβ, VEGF), which have been implicated in tumor growth and/or metastasis. This article reviews published models for studying interactions between MSC and cancer cells with a focus on the impact of MSC secretome on cancer cell activity, and discusses the implications for regenerative therapy after cancer.
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影响因子：
3.7
作者：
Boomsma RA;Geenen DL
通讯作者：
Geenen DL
影响因子：
4.1
作者：
Casteilla, Louis;Planat-Benard, Valerie;Cousin, Beatrice
通讯作者：
Cousin, Beatrice
影响因子：
5.7
作者：
Bian, Zhen-Yu;Fan, Qi-Ming;Tang, Ting-Ting
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DOI：
10.1111/j.1749-6632.2012.06667.x
发表时间：
2012-01-01
期刊：
HEMATOPOIETIC STEM CELLS VIII
影响因子：
--
作者：
Bernardo, Maria Ester;Fibbe, Willem E.
通讯作者：
Fibbe, Willem E.
影响因子：
11.4
作者：
Corre, J.;Mahtouk, K.;Bourin, P.
通讯作者：
Bourin, P.