Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia.
Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia.
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DOI：
10.1016/j.neuroimage.2011.07.054
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发表时间：
2012-01-02
期刊：
影响因子：
5.7
通讯作者：
Altshuler LL
中科院分区：
文献类型：
--
作者：
Foland-Ross LC;Bookheimer SY;Lieberman MD;Sugar CA;Townsend JD;Fischer J;Torrisi S;Penfold C;Madsen SK;Thompson PM;Altshuler LL
功能性神经影像学研究表明，杏仁核和腹外侧前额叶皮质（vlPFC）参与了双相情感障碍的病理生理过程。据报道，在情感面孔任务的表现过程中，双相躁狂患者的杏仁核活动过度和前额叶皮质功能减退。这种功能障碍的模式是否在心境正常时持续存在尚不清楚。使用功能性磁共振成像（fMRI），24 euthymic双极和26人口统计学匹配的健康对照组进行扫描，同时进行情感任务范式，涉及匹配和标记的情绪面部表情。神经影像学结果表明，虽然杏仁核激活没有显着差异组之间，正常的患者表现出显着减少激活的右vlPFC（BA47）相比，健康对照组在情绪标签。此外，在情绪标记条件下，相对于健康对照受试者，在正常胸腺双极中观察到右丘脑、壳核、丘脑和舌回的激活显著减少。这些数据，采取的背景下与双相躁狂症使用相同的情绪识别任务的先前研究，可以表明，杏仁核功能障碍可能是一个状态相关的异常在双相情感障碍，而vlPFC功能障碍可能代表一个性状相关的异常的疾病。表征这些激活模式可能有助于理解与双相情感障碍中不同情绪状态相关的神经变化，以及代表更持续异常的变化。未来的研究，评估情绪状态相关的变化，在纵向双极样本的大脑激活将是有趣的。
Functional neuroimaging studies have implicated the involvement of the amygdala and ventrolateral prefrontal cortex (vlPFC) in the pathophysiology of bipolar disorder. Hyperactivity in the amygdala and hypoactivity in the vlPFC have been reported in manic bipolar patients scanned during the performance of an affective faces task. Whether this pattern of dysfunction persists during euthymia is unclear. Using functional magnetic resonance imaging (fMRI), 24 euthymic bipolar and 26 demographically matched healthy control subjects were scanned while performing an affective task paradigm involving the matching and labeling of emotional facial expressions. Neuroimaging results showed that, while amygdala activation did not differ significantly between groups, euthymic patients showed a significant decrease in activation of the right vlPFC (BA47) compared to healthy controls during emotion labeling. Additionally, significant decreases in activation of the right insula, putamen, thalamus and lingual gyrus were observed in euthymic bipolar relative to healthy control subjects during the emotion labeling condition. These data, taken in context with prior studies of bipolar mania using the same emotion recognition task, could suggest that amygdala dysfunction may be a state-related abnormality in bipolar disorder, whereas vlPFC dysfunction may represent a trait-related abnormality of the illness. Characterizing these patterns of activation is likely to help in understanding the neural changes related to the different mood states in bipolar disorder, as well as changes that represent more sustained abnormalities. Future studies that assess mood-state related changes in brain activation in longitudinal bipolar samples would be of interest.
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