GeneCards Version 3: the human gene integrator.
GeneCards Version 3: the human gene integrator.
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DOI：
10.1093/database/baq020
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发表时间：
2010-08-05
期刊：
影响因子：
--
通讯作者：
Lancet D
中科院分区：
文献类型：
--
作者：
Safran M;Dalah I;Alexander J;Rosen N;Iny Stein T;Shmoish M;Nativ N;Bahir I;Doniger T;Krug H;Sirota-Madi A;Olender T;Golan Y;Stelzer G;Harel A;Lancet D
GeneCards（www.genecards.org）是一个关于人类基因注释信息的全面、权威的纲要，广泛使用了近15年。其以基因为中心的内容是从80多个数字来源中自动挖掘和整合的，从而为超过73000个人类基因条目中的每一个产生基于网络的深度链接卡，包括以下类别：蛋白质编码，假基因，RNA基因，遗传位点，簇和未分类。我们现在推出GeneCards第三版，其特点是快速和复杂的搜索引擎和经过改造的技术支持基础设施，以满足生物医学研究人员不断扩大的需求。一个关键的重点是基因集分析，利用基因卡的组合注释的独特财富。这些包括GeneAlaCart批量查询设施，它将用户选择的多个基因的注释和GeneDecks制成表格，它识别具有共享注释的相似基因，并通过描述符富集分析找到集合共享注释。这种以集合为中心的特征解决了许多应用，包括微阵列数据分析、跨数据库注释映射和用于药物靶向的基因-病症关联。我们强调新的版本3数据库架构，其多方面的搜索引擎，其半自动化的质量保证系统。数据增强包括正常和癌症组织中基因表达模式的扩展可视化，整合的选择性剪接模式显示，以及增强的多源SNP和途径部分。GeneCards现在提供与基因相关的研究试剂的直接链接，如抗体、重组蛋白、DNA克隆和抑制性RNA，并提供与基因相关的药物和化合物列表。我们还描绘了基因卡推断功能评分注释景观工具，用于评分基因的功能信息状态。最后，我们描绘的应用程序和合作，受益于GeneCards套件的例子。数据库URL：www.genecards.org
GeneCards (www.genecards.org) is a comprehensive, authoritative compendium of annotative information about human genes, widely used for nearly 15 years. Its gene-centric content is automatically mined and integrated from over 80 digital sources, resulting in a web-based deep-linked card for each of >73 000 human gene entries, encompassing the following categories: protein coding, pseudogene, RNA gene, genetic locus, cluster and uncategorized. We now introduce GeneCards Version 3, featuring a speedy and sophisticated search engine and a revamped, technologically enabling infrastructure, catering to the expanding needs of biomedical researchers. A key focus is on gene-set analyses, which leverage GeneCards’ unique wealth of combinatorial annotations. These include the GeneALaCart batch query facility, which tabulates user-selected annotations for multiple genes and GeneDecks, which identifies similar genes with shared annotations, and finds set-shared annotations by descriptor enrichment analysis. Such set-centric features address a host of applications, including microarray data analysis, cross-database annotation mapping and gene-disorder associations for drug targeting. We highlight the new Version 3 database architecture, its multi-faceted search engine, and its semi-automated quality assurance system. Data enhancements include an expanded visualization of gene expression patterns in normal and cancer tissues, an integrated alternative splicing pattern display, and augmented multi-source SNPs and pathways sections. GeneCards now provides direct links to gene-related research reagents such as antibodies, recombinant proteins, DNA clones and inhibitory RNAs and features gene-related drugs and compounds lists. We also portray the GeneCards Inferred Functionality Score annotation landscape tool for scoring a gene’s functional information status. Finally, we delineate examples of applications and collaborations that have benefited from the GeneCards suite. Database URL: www.genecards.org
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影响因子：
5.8
作者：
Rosen, Naomi;Chalifa-Caspi, Vered;Lancet, Doron
通讯作者：
Lancet, Doron
影响因子：
5.8
作者：
Safran, M;Solomon, I;Lancet, D
通讯作者：
Lancet, D
影响因子：
14.9
作者：
Safran, M;Chalifa-Caspi, V;Lancet, D
通讯作者：
Lancet, D
影响因子：
3
作者：
Harel, Arye;Inger, Aron;Lancet, Doron
通讯作者：
Lancet, Doron
影响因子：
11.4
作者：
Rebhan, M;ChalifaCaspi, V;Lancet, D
通讯作者：
Lancet, D