SU-8 microprobe with microelectrodes for monitoring electrical impedance in living tissues.
SU-8 microprobe with microelectrodes for monitoring electrical impedance in living tissues.
复制标题
带微电极的 SU-8 微探针，用于监测活体组织中的电阻抗。
DOI：
10.1016/j.bios.2008.12.019
复制
发表时间：
2009
影响因子：
12.6
通讯作者：
Luis J. Fernández
中科院分区：
文献类型：
--
作者：
M. Tijero;Gemma Gabriel;Gemma Gabriel;J. Caro;Ane Altuna;R. M. Hernandez;Rosa Villa;Rosa Villa;J. Berganzo;F. Blanco;R. Salido;Luis J. Fernández
本文提出了一种微创针形探头能够监测电阻抗的活组织。该微探针由160μm厚的SU-8基片组成，基片上有四个平面铂（Pt）微电极。我们设计的探针可以最大限度地减少对周围组织的损伤，并具有足够的硬度以插入活组织中。所提出的批量制造工艺成本低，耗时少。用这种方法得到的微电极牢固地粘附在SU-8基板上，并且它们的阻抗不依赖于频率变化。在体外实验与以前开发的Si和SiC为基础的微探针和结果表明，它是优选的使用SU-8为基础的微探针，由于其灵活性和低成本。微探针用导电胶组装在柔性印刷电路FPC上，用环氧树脂封装并连接到外部仪器。这种灵活的探针插入到大鼠肾脏没有骨折，并成功地证明了缺血监测。
This paper presents a minimally invasive needle-shaped probe capable of monitoring the electrical impedance of living tissues. This microprobe consists of a 160μm thick SU-8 substrate containing four planar platinum (Pt) microelectrodes. We design the probe to minimize damage to the surrounding tissue and to be stiff enough to be inserted in living tissues. The proposed batch fabrication process is low cost and low time consuming. The microelectrodes obtained with this process are strongly adhered to the SU-8 substrate and their impedance does not depend on frequency variation. In vitro experiments are compared with previously developed Si and SiC based microprobes and results suggest that it is preferable to use the SU-8 based microprobes due to their flexibility and low cost. The microprobe is assembled on a flexible printed circuit FPC with a conductive glue, packaged with epoxy and wired to the external instrumentation. This flexible probe is inserted into a rat kidney without fracturing and succeeds in demonstrating the ischemia monitoring.
影响因子：
14
作者：
Voskerician, G;Shive, MS;Langer, R
通讯作者：
Langer, R