The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation.
The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation.
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DOI：
10.1084/jem.20141849
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发表时间：
2015-05-04
期刊：
影响因子：
--
通讯作者：
Verykokakis M
中科院分区：
文献类型：
--
作者：
Carr T;Krishnamoorthy V;Yu S;Xue HH;Kee BL;Verykokakis M
The transcription factor LEF1 promotes the expansion and Th2-type polarization of invariant NKT cells in part by directly inducing the expression of the IL-7 receptor component CD127 and the transcription factors c-myc and Gata3. Invariant natural killer T cells (iNKT cells) are innate-like T cells that rapidly produce cytokines that impact antimicrobial immune responses, asthma, and autoimmunity. These cells acquire multiple effector fates during their thymic development that parallel those of CD4+ T helper cells. The number of Th2-type effector iNKT cells is variable in different strains of mice, and their number impacts CD8 T, dendritic, and B cell function. Here we demonstrate a unique function for the transcription factor lymphoid enhancer factor 1 (LEF1) in the postselection expansion of iNKT cells through a direct induction of the CD127 component of the receptor for interleukin-7 (IL-7) and the transcription factor c-myc. LEF1 also directly augments expression of the effector fate–specifying transcription factor GATA3, thus promoting the development of Th2-like effector iNKT cells that produce IL-4, including those that also produce interferon-γ. Our data reveal LEF1 as a central regulator of iNKT cell number and Th2-type effector differentiation.
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影响因子：
32.4
作者：
Malhotra N;Narayan K;Cho OH;Sylvia KE;Yin C;Melichar H;Rashighi M;Lefebvre V;Harris JE;Berg LJ;Kang J;Immunological Genome Project Consortium
通讯作者：
Immunological Genome Project Consortium
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
4.5
作者：
Grumolato, Luca;Liu, Guizhong;Aaronson, Stuart A.
通讯作者：
Aaronson, Stuart A.
DOI：
10.1084/jem.20050456
发表时间：
2005-08-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Benlagha K;Wei DG;Veiga J;Teyton L;Bendelac A
通讯作者：
Bendelac A
DOI：
10.1073/pnas.0604773103
发表时间：
2006-12-05
影响因子：
11.1
作者：
Lim, S. Kyun;Hoffmann, F. Michael
通讯作者：
Hoffmann, F. Michael