Increased carotid intima-media thickness in patients with pheochromocytoma in comparison to essential hypertension
Increased carotid intima-media thickness in patients with pheochromocytoma in comparison to essential hypertension
复制标题
与原发性高血压患者相比，嗜铬细胞瘤患者颈动脉内膜中层厚度增加
DOI：
10.1038/jhh.2008.130
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发表时间：
2009
影响因子：
2.7
通讯作者：
J. Widimský
中科院分区：
文献类型：
--
作者：
R. Holaj;T. Zelinka;D. Wichterle;O. Petrák;B. Štrauch;A. Vránková;B. Majtan;Jiří Spáčil;Jan Malik;J. Widimský
儿茶酚胺由于各种机制可能有助于胶原纤维和细胞外基质在动脉壁中的积累。本研究的目的是比较嗜铬细胞瘤、原发性高血压患者和健康对照组的颈总动脉 (CCA) 和颈动脉分叉 (CB) 的内膜中层厚度 (IMT)。对 30 名年龄和性别相匹配的嗜铬细胞瘤患者、80 名原发性高血压患者和 40 名血压正常对照者进行了颈动脉超声研究。在 CCA 中测量时，发现嗜铬细胞瘤和原发性高血压患者的 IMT 显着高于对照组（0.931±0.223、0.825±0.146 和 0.738±0.113mm；P<0.001；P<0.05），并且仅在 CB 区域的嗜铬细胞瘤患者中与对照组相比。 （1.359±0.593、1.095±0.311 和 0.968±0.247mm；P<0.001；P=0.13）。与原发性高血压患者相比，嗜铬细胞瘤患者的 IMT 较高，在两个颈动脉区域也具有统计学意义（均 P<0.01）。在对 CCA 中的所有相关临床和生化协变量进行调整后，这种差异仍然显着（P=0.014），但在 CB 区域中消失了（P=0.079）。总之，与原发性高血压患者相比，嗜铬细胞瘤患者颈总动脉 IMT 增加。这一发现可能是由于过量的儿茶酚胺对血管壁生长和增厚的有害影响造成的。
Catecholamines due to various mechanisms may contribute to the accumulation of collagen fibers and extracellular matrix in the arterial wall. The aim of this study was to compare intima-media thickness (IMT) of the common carotid artery (CCA) and carotid bifurcation (CB) in patients with pheochromocytoma, essential hypertension and healthy controls. Carotid ultrasound studies were carried out in 30 patients with pheochromocytoma matched for age and gender with 80 patients with essential hypertension and 40 normotensive controls. Significantly higher IMT was found in patients with pheochromocytoma and essential hypertension compared to controls when measured in the CCA (0.931±0.223, 0.825±0.146 and 0.738±0.113 mm; P<0.001; P<0.05), and only in patients with pheochromocytoma compared to controls in the region of CB (1.359±0.593, 1.095±0.311 and 0.968±0.247 mm; P<0.001; P=0.13). Higher IMT in patients with pheochromocytoma compared to patients with essential hypertension was also statistically significant in both carotid regions (both P<0.01). This difference remained significant after adjustment for all relevant clinical and biochemical covariates in the CCA (P=0.014) but disappeared in the region of CB (P=0.079). In summary, patients with pheochromocytoma have increased common carotid IMT when compared to patients with essential hypertension. This finding could be caused by the deleterious effects of the excess of catecholamines on the vascular wall growth and thickening.
大鼠慢性儿茶酚胺输注期间的高血压和心血管肥大。
影响因子：
6.1
作者：
Johnson,MD;Grignolo,A;Kuhn,CM;Schanberg,SM
通讯作者：
Schanberg,SM
DOI：
10.1152/ajpheart.00218.2002
发表时间：
2002-10-01
影响因子：
4.8
作者：
Erami, C;Zhang, H;Faber, JE
通讯作者：
Faber, JE