CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut.
CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut.
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DOI：
10.1016/j.immuni.2010.12.009
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发表时间：
2011-01-28
期刊：
影响因子：
32.4
通讯作者：
Artis D
中科院分区：
文献类型：
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作者：
Sonnenberg GF;Monticelli LA;Elloso MM;Fouser LA;Artis D
胎儿CD 4+淋巴组织诱导（LTi）细胞在淋巴组织的发育中起关键作用。最近的研究表明，LTi细胞在成人中持续存在，并且与参与炎症反应的先天淋巴细胞的异质群体有关。然而，LTi细胞是否有助于保护性免疫仍然不清楚。我们证明，感染啮齿类柠檬酸杆菌后，CD 4 + LTi细胞是感染早期白细胞介素-22（IL-22）的主要来源。感染诱导的CD 4 + LTi细胞反应是IL-23依赖性的，IL-23的消除会损害先天免疫。此外，CD 4 + LTi细胞的耗竭消除了感染诱导的IL-22和抗微生物肽的表达，导致宿主死亡率加剧。LTi细胞也被发现是必不可少的宿主保护性免疫在淋巴细胞充盈的主机。总的来说，这些数据表明，成人CD 4 + LTi细胞是IL-22的关键来源，并确定了CD 4 + LTi细胞在促进肠道先天免疫中的先前未被认识的功能。
Fetal CD4+ lymphoid tissue inducer (LTi) cells play a critical role in the development of lymphoid-tissues. Recent studies identified that LTi cells persist in adults and are related to a heterogeneous population of innate lymphoid cells that have been implicated in inflammatory responses. However, whether LTi cells contribute to protective immunity remains poorly defined. We demonstrate that following infection with Citrobacter rodentium, CD4+ LTi cells were a dominant source of interleukin-22 (IL-22) early during infection. Infection-induced CD4+ LTi cell responses were IL-23-dependent, and ablation of IL-23 impaired innate immunity. Further, depletion of CD4+ LTi cells abrogated infection-induced expression of IL-22 and anti-microbial peptides, resulting in exacerbated host mortality. LTi cells were also found to be essential for host protective immunity in lymphocyte-replete hosts. Collectively these data demonstrate that adult CD4+ LTi cells are a critical source of IL-22 and identify a previously unrecognized function for CD4+ LTi cells in promoting innate immunity in the intestine.
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