Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy.
Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy.
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DOI：
10.1016/j.pain.2011.03.002
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发表时间：
2011-07
期刊：
影响因子：
7.4
通讯作者：
Porreca F
中科院分区：
文献类型：
--
作者：
Qu C;King T;Okun A;Lai J;Fields HL;Porreca F
神经性疼痛通常是“自发的”或“与刺激无关的”。这种疼痛可能是由受损周围神经的初级传入伤害感受器的自发放电引起的。然而，轴突切除的初级传入伤害感受器是否会引起疼痛尚不清楚。头侧前扣带皮层（rACC）介导炎性疼痛的负面情感成分。 rACC 是否整合了神经损伤引起的慢性自发性疼痛的厌恶成分尚不清楚。在这里，我们使用负强化原理来表明轴切术产生一种厌恶状态，反映了受伤神经驱动的自发疼痛。此外，我们还研究了 rACC 是否会导致神经损伤引起的自发性疼痛的厌恶。分别通过坐骨或坐骨/隐神经轴索切断术产生部分或完全后爪去神经支配。在接受坐骨神经轴索切断术的脊髓可乐定动物身上观察到了因假定的疼痛缓解而产生的条件性位置偏好，但在假手术对照中却没有观察到。类似地，将利多卡因注射到延髓头侧腹内侧（RVM）中，在坐骨/隐神经轴索切断术的动物中选择性地产生位置偏好。在脊髓神经结扎 (SNL) 损伤的大鼠中，rACC 损伤阻断了 RVM 利多卡因引起的奖赏，但没有改变急性刺激诱发的超敏反应。 rACC 的损伤不会阻断可卡因诱导的奖赏，这表明 rACC 阻断不会损害记忆编码或检索，但会损害自发的厌恶性。这些数据表明，由受损神经纤维引起的自发性疼痛会产生由 rACC 介导的强直厌恶状态。识别介导慢性疼痛厌恶的回路应该有助于开发改进的疗法。
Neuropathic pain is often “spontaneous” or “stimulus-independent.” Such pain may result from spontaneous discharge in primary afferent nociceptors in injured peripheral nerves. However, whether axotomized primary afferent nociceptors give rise to pain is unclear. The rostral anterior cingulate cortex (rACC) mediates the negative affective component of inflammatory pain. Whether the rACC integrates the aversive component of chronic spontaneous pain arising from nerve injury is not known. Here, we used the principle of negative reinforcement to show that axotomy produces an aversive state reflecting spontaneous pain driven from injured nerves. Additionally, we investigated whether the rACC contributes to the aversiveness of nerve injury induced spontaneous pain. Partial or complete hindpaw denervation was produced by sciatic or sciatic/saphenous axotomy, respectively. Conditioned place preference resulting from presumed pain relief was observed following spinal clonidinein animals with sciatic axotomy but not in sham-operated controls. Similarly, lidocaine administration into the rostral ventromedial medulla (RVM) produced place preference selectively in animals with sciatic/saphenous axotomy. In rats with spinal nerve ligation (SNL) injury lesion of the rACC blocked the reward elicited by RVM lidocaine but did not alter acute stimulus evoked hypersensitivity. Lesion of the rACC did not block cocaine-induced reward indicating that rACC blockade did not impair memory encoding or retrieval but did impair spontaneous aversiveness. These data indicate that spontaneous pain arising from injured nerve fibers produces a tonic aversive state that is mediated by the rACC. Identification of the circuits mediating aversiveness of chronic pain should facilitate the development of improved therapies.
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影响因子：
2.5
作者：
Koyama, T;Kato, K;Mikami, A
通讯作者：
Mikami, A
DOI：
10.1073/pnas.96.14.7668
发表时间：
1999-07-06
影响因子：
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作者：
Casey, KL
通讯作者：
Casey, KL
影响因子：
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作者：
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通讯作者：
Smith, PA
影响因子：
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作者：
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通讯作者：
Minoshima, S
影响因子：
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作者：
FOLTZ, EL;WHITE, LE
通讯作者：
WHITE, LE