Hematopoietic stem cell fate through metabolic control.
Hematopoietic stem cell fate through metabolic control.
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DOI：
10.1016/j.exphem.2018.05.005
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发表时间：
2018-08
影响因子：
2.6
通讯作者：
Ito K
中科院分区：
文献类型：
--
作者：
Ito K;Ito K
造血干细胞（hsc）在骨髓中保持静止状态以保持其自我更新能力，但也会根据需要进行细胞分裂。细胞器如线粒体在这些细胞分裂过程中持续累积损伤，这种损伤最终可能损害细胞的自我更新能力。造血干细胞分裂导致自我更新或分化，两者之间的平衡直接影响造血稳态；但可获得的造血干细胞富集组分的异质性，以及观察造血干细胞行为的技术挑战，长期以来阻碍了对单个造血干细胞的分析，并阻碍了对这一过程的阐明。然而，遗传模型、代谢组学分析和单细胞方法的最新进展揭示了代谢线索、线粒体生物发生和自噬/线粒体自噬对HSC自我更新的贡献，这突出了线粒体质量是HSC平衡的关键控制因素。因此，更深入地了解特定的代谢模式如何在单细胞水平上精确地控制HSC的命运，不仅具有重大的生物学意义，而且对血液病治疗的发展具有明确的临床意义。
Hematopoietic stem cells (HSCs) maintain a quiescent state in the bone marrow to preserve their self-renewal capacity, but also undergo cell divisions as required. Organelles such as the mitochondria sustain cumulative damage during these cell divisions, and this damage may eventually compromise the cells’ self-renewal capacity. HSC divisions result in either self-renewal or differentiation, with the balance between the two directly impacting hematopoietic homeostasis; but the heterogeneity of available HSC-enriched fractions, together with the technical challenges of observing HSC behavior, has long hindered the analysis of individual HSCs, and prevented the elucidation of this process. However, recent advances in genetic models, metabolomics analyses and single-cell approaches have revealed the contributions made to HSC self-renewal by metabolic cues, mitochondrial biogenesis, and autophagy/mitophagy, which have highlighted mitochondrial quality as a key control factor in the equilibrium of HSCs. A deeper understanding of precisely how specific modes of metabolism control HSC fate at the single cell level is therefore not only of great biological interest, but will have clear clinical implications for the development of therapies for hematological disease.
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影响因子：
64.5
作者：
Bernitz, Jeffrey M.;Kim, Huen Suk;MacArthur, Ben;Sieburg, Hans;Moore, Kateri
通讯作者：
Moore, Kateri
影响因子：
17.1
作者：
Doulatov S;Vo LT;Macari ER;Wahlster L;Kinney MA;Taylor AM;Barragan J;Gupta M;McGrath K;Lee HY;Humphries JM;DeVine A;Narla A;Alter BP;Beggs AH;Agarwal S;Ebert BL;Gazda HT;Lodish HF;Sieff CA;Schlaeger TM;Zon LI;Daley GQ
通讯作者：
Daley GQ
影响因子：
50.3
作者：
Figueroa ME;Abdel-Wahab O;Lu C;Ward PS;Patel J;Shih A;Li Y;Bhagwat N;Vasanthakumar A;Fernandez HF;Tallman MS;Sun Z;Wolniak K;Peeters JK;Liu W;Choe SE;Fantin VR;Paietta E;Löwenberg B;Licht JD;Godley LA;Delwel R;Valk PJ;Thompson CB;Levine RL;Melnick A
通讯作者：
Melnick A
影响因子：
23.9
作者：
Duarte D;Hawkins ED;Akinduro O;Ang H;De Filippo K;Kong IY;Haltalli M;Ruivo N;Straszkowski L;Vervoort SJ;McLean C;Weber TS;Khorshed R;Pirillo C;Wei A;Ramasamy SK;Kusumbe AP;Duffy K;Adams RH;Purton LE;Carlin LM;Lo Celso C
通讯作者：
Lo Celso C
影响因子：
64.8
作者：
Chen JY;Miyanishi M;Wang SK;Yamazaki S;Sinha R;Kao KS;Seita J;Sahoo D;Nakauchi H;Weissman IL
通讯作者：
Weissman IL