The Impact of the Tumor Microenvironment on the Properties of Glioma Stem-Like Cells.
The Impact of the Tumor Microenvironment on the Properties of Glioma Stem-Like Cells.
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DOI：
10.3389/fonc.2017.00143
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发表时间：
2017
影响因子：
4.7
通讯作者：
Bhat KPL
中科院分区：
文献类型：
--
作者：
Audia A;Conroy S;Glass R;Bhat KPL
胶质母细胞瘤是最常见和高度恶性的原发性脑肿瘤，患有这种疾病的患者表现出一致的悲观预后。胶质瘤干细胞样细胞（GSC）是肿瘤内的细胞亚群，具有与成体干细胞类似的自我更新和多谱系分化特性。这些细胞也位于细胞层次结构的顶端，并在化疗后引起肿瘤的发生和扩张。这些特征使它们成为治疗开发的有吸引力的目标。由于 GSC 的生长依赖于大脑微环境，并且微环境中的非致瘤细胞类型可以影响 GSC 表型和治疗反应，因此需要更好地了解这些细胞类型。在这篇综述中，我们重点概述了微环境对 GSC 归巢、维持、表型可塑性和肿瘤发生的贡献。讨论了 GSC 与血管室、间充质干细胞、免疫系统和正常脑细胞类型的相互作用。未来有必要开展研究来深入了解 GSC 与微环境相互作用的机制。
Glioblastoma is the most common and highly malignant primary brain tumor, and patients affected with this disease exhibit a uniformly dismal prognosis. Glioma stem-like cells (GSCs) are a subset of cells within the bulk tumor that possess self-renewal and multi-lineage differentiation properties similar to somatic stem cells. These cells also are at the apex of the cellular hierarchy and cause tumor initiation and expansion after chemo-radiation. These traits make them an attractive target for therapeutic development. Because GSCs are dependent on the brain microenvironment for their growth, and because non-tumorigenic cell types in the microenvironment can influence GSC phenotypes and treatment response, a better understanding of these cell types is needed. In this review, we provide a focused overview of the contributions from the microenvironment to GSC homing, maintenance, phenotypic plasticity, and tumor initiation. The interaction of GSCs with the vascular compartment, mesenchymal stem cells, immune system, and normal brain cell types are discussed. Studies that provide mechanistic insight into each of these GSC–microenvironment interactions are warranted in the future.
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胶质瘤干细胞增殖和肿瘤生长由一氧化氮合酶2促进。
影响因子：
64.5
作者：
Eyler CE;Wu Q;Yan K;MacSwords JM;Chandler-Militello D;Misuraca KL;Lathia JD;Forrester MT;Lee J;Stamler JS;Goldman SA;Bredel M;McLendon RE;Sloan AE;Hjelmeland AB;Rich JN
通讯作者：
Rich JN
神经胶质瘤干细胞衍生外泌体的全身性T细胞免疫抑制是由单核细胞衍生的抑制细胞介导的。
影响因子：
3.7
作者：
Domenis R;Cesselli D;Toffoletto B;Bourkoula E;Caponnetto F;Manini I;Beltrami AP;Ius T;Skrap M;Di Loreto C;Gri G
通讯作者：
Gri G
影响因子：
64.5
作者：
Bonaguidi MA;Wheeler MA;Shapiro JS;Stadel RP;Sun GJ;Ming GL;Song H
通讯作者：
Song H
影响因子：
4.7
作者：
Enderling H;Hlatky L;Hahnfeldt P
通讯作者：
Hahnfeldt P
影响因子：
2.5
作者：
Badie, B;Schartner, J
通讯作者：
Schartner, J