Berberine modulates deacetylation of PPARγ to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway.
Berberine modulates deacetylation of PPARγ to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway.
复制标题
小檗碱通过 AMPK/SIRT1 途径调节 PPAR γ 脱乙酰化促进脂肪组织重塑和产热
DOI：
10.7150/ijbs.62556
复制
发表时间：
2021
影响因子：
9.2
通讯作者：
Cao L
中科院分区：
文献类型：
--
作者：
Xu Y;Yu T;Ma G;Zheng L;Jiang X;Yang F;Wang Z;Li N;He Z;Song X;Wen D;Kong J;Yu Y;Cao L
据报道，脂肪组织的重塑和生热的模拟预计将是肥胖的可行治疗策略。 We have further demonstrated that berberine activated energy metabolic sensitivity pathway AMPK/SIRT1 axis to increase the level of PPARγ deacetylation, which leads to promoting adipose tissue remodeling and increasing the expression of the thermogenic protein UCP-1. These findings suggest that berberine that enhances the AMPK/SIRT1 pathway can act as a selective PPARγ activator to promote adipose tissue remodeling and thermogenesis. This study proposals用于调节脂肪组织中柏碱的新机制，为肥胖症治疗提供了良好的前景
Pharmacological stimulation of adipose tissue remodeling and thermogenesis to increase energy expenditure is expected to be a viable therapeutic strategy for obesity. Berberine has been reported to have pharmacological activity in adipose tissue to anti-obesity, while the mechanism remains unclear. Here, we observed that berberine significantly reduced the body weight and insulin resistance of high-fat diet mice by promoting the distribution of brown adipose tissue and thermogenesis. We have further demonstrated that berberine activated energy metabolic sensing pathway AMPK/SIRT1 axis to increase the level of PPARγ deacetylation, which leads to promoting adipose tissue remodeling and increasing the expression of the thermogenic protein UCP-1. These findings suggest that berberine that enhances the AMPK/SIRT1 pathway can act as a selective PPARγ activator to promote adipose tissue remodeling and thermogenesis. This study proposes a new mechanism for the regulation of berberine in adipose tissue and offers a great prospect for berberine in obesity treatment
登录
查看更多内容
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
5.4
作者：
Gao, N.;Zhao, T-Y;Li, X-J
通讯作者：
Li, X-J
ATM-CHK2-Beclin 1轴促进自噬以维持氧化应激下ROS稳态
影响因子：
11.4
作者：
Guo, Qi-Qiang;Wang, Shan-Shan;Cao, Liu
通讯作者：
Cao, Liu
影响因子：
8.3
作者：
Aigner, Annette;Grittner, Ulrike;Busch, Markus A.
通讯作者：
Busch, Markus A.
影响因子：
4.6
作者：
Chow YL;Sogame M;Sato F
通讯作者：
Sato F