Medication Adherence Aligns with Age and a Behavioral Checklist but Not Symptoms or Quality of Life for Patients with Eosinophilic Esophagitis.
Medication Adherence Aligns with Age and a Behavioral Checklist but Not Symptoms or Quality of Life for Patients with Eosinophilic Esophagitis.
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DOI：
10.1016/j.jpeds.2021.03.047
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Menard-Katcher C
中科院分区：
文献类型：
--
作者：
Mehta P;Pan Z;Skirka S;Kwan BM;Menard-Katcher C
测量嗜酸性粒细胞性食管炎（EoE）儿童吞咽外用类固醇的依从性，描述与依从性相关的因素，并确定EoE儿童的依从性、症状、感知疾病严重程度和生活质量之间的相关性。在这项横断面研究中，117名5-18岁的EoE儿童的受试者完成了儿科嗜酸性食管炎症状评分V2.0（PEESS）、儿科生活质量量表嗜酸性食管炎模块（PedsQL EoE）、用药清单（MTC）和人口统计学问卷。根据上周报告的漏服剂量/处方剂量数量计算依从率。5-12岁儿童采用父母报告的测量方法，13-18岁儿童采用自我报告的方法。青少年的依从率低于年幼儿童（76.2 ± 24.5% vs 88.6 ± 16.7%，P = 0.002）。依从率与病史、PEESS或PedsQL™ EoE评分无关，但与MTC评分相关（Pearson r = 0.65，儿童报告P<0.001，父母报告Pearsonr = 0.74，P<0.001）。症状与生活质量差相关（PEESS频率：r=-0.7，P<0.001; PEESS严重程度：5-12岁儿童r=-0.71，P<0.001; PEESS频率：r =-0.61，P<0.001; PEESS严重程度：青少年r=-0.5，P<0.001）。与他们的临床病史、人口统计学因素、症状和生活质量无关，青少年EoE的药物依从性较低。MTC可以作为临床工具来讨论依从性，并提供关于依从性干预的有针对性的教育咨询。
To measure adherence rates to swallowed topical steroids in children with eosinophilic esophagitis (EoE), describe factors related to adherence, and determine the association between adherence, symptoms, perceived disease severity, and quality of life in children with EoE. Subjects in this cross-sectional study of 117 children between 5–18 years old with EoE completed the Pediatric Eosinophilic Esophagitis Symptoms Score V2.0 (PEESS), Pediatric Quality of Life Inventory Eosinophilic Esophagitis Module (PedsQL EoE), a Medication-Taking Checklist (MTC), and a demographics questionnaire. Adherence rate was calculated based on reported number of missed doses/prescribed doses in the last week. Parent-reported measures were used for children aged 5–12 years and self-report was used for children aged 13–18 years. Adolescents had lower adherence rates than younger children (76.2 ± 24.5% versus 88.6 ± 16.7%, P =.002). Adherence rates were not associated with disease history, PEESS or PedsQL™ EoE scores, but instead correlated with MTC scores (Pearson r o f0.65, P<.001 for child-report and Pearsonr of 0.74, P<.001 for parent-report). Symptomatology was associated with worse quality of life (PEESS Frequency: r=-0.7, P<0.001; PEESS Severity: r=-0.71, P<.001 for children 5–12 years old; PEESS Frequency: r-0.61, P<0.001; PEESS Severity: r=-0.5, P<.001 for adolescents). Unrelated to their clinical history, demographic factors, symptoms, and quality of life, adolescents with EoE have lower medication adherence rates. The MTC may serve as a clinical tool to discuss adherence and provide targeted educational counseling regarding adherence interventions.
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DOI：
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发表时间：
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影响因子：
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作者：
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