Coordination of DNA replication and recombination activities in the maintenance of genome stability.
Coordination of DNA replication and recombination activities in the maintenance of genome stability.
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DOI：
10.1002/jcb.23211
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发表时间：
2011-10
影响因子：
4
通讯作者：
Morrical, Scott W.
中科院分区：
文献类型：
--
作者：
Maher, Robyn L.;Branagan, Amy M.;Morrical, Scott W.
在整个进化谱中，生物体依赖于高保真DNA复制和重组机制来维持基因组稳定性，从而避免突变和疾病。DNA中严重损伤的修复，如双链断裂或停滞的复制叉，需要同源重组和DNA复制机制的协调活动。越来越多的证据表明，这两个系统中所谓的“辅助蛋白”对于重组与复制的有效偶联是必不可少的，这是在严重DNA损伤后恢复基因组完整性所必需的。本文综述了同源定向DNA修复（HDR）的主要过程，包括双Holliday连接（dHJ）、合成依赖性链退火（SDSA）、断裂诱导复制（BIR）和无错误损伤旁路途径。这些途径中的每一个都涉及同源重组事件与DNA合成的偶联。我们强调了两类主要的辅助蛋白在重组和复制，促进HDR：转录介质蛋白的例子T4 UvsY，S。酿酒酵母Rad 52和人BRCA 2;和DNA解旋酶/易位酶，例如T4 Gp 41/Gp 59，E. coli DnaB和PriA，以及真核细胞Mcm 2 -7、Rad 54和Mph 1。我们说明了这些因素如何帮助引导DNA和蛋白质-DNA中间体从双链断裂或停滞的复制叉到高保真重组依赖性复制装置的途径上的流动，该复制装置可以准确地修复损伤。
Across the evolutionary spectrum, living organisms depend on high-fidelity DNA replication and recombination mechanisms to maintain genome stability and thus to avoid mutation and disease. The repair of severe lesions in the DNA such as double-strand breaks or stalled replication forks requires the coordinated activities of both the homologous recombination and DNA replication machineries. Growing evidence indicates that so-called “accessory proteins” in both systems are essential for the effective coupling of recombination to replication that is necessary to restore genome integrity following severe DNA damage. In this article we review the major processes of homology-directed DNA repair (HDR), including the double Holliday Junction (dHJ), synthesis-dependent strand annealing (SDSA), break-induced replication (BIR), and error-free lesion bypass pathways. Each of these pathways involves the coupling of a homologous recombination event to DNA synthesis. We highlight two major classes of accessory proteins in recombination and replication that facilitate HDR: Recombination mediator proteins exemplified by T4 UvsY, S. cerevisiae Rad52, and human BRCA2; and DNA helicases/translocases exemplified by T4 Gp41/Gp59, E. coli DnaB and PriA, and eukaryotic Mcm2-7, Rad54, and Mph1. We illustrate how these factors help to direct the flow of DNA and protein-DNA intermediates on the pathway from a double-strand break or stalled replication fork to a high-fidelity recombination-dependent replication apparatus that can accurately repair the damage.
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DOI：
10.3109/10409238.2011.576007
发表时间：
2011-06
影响因子：
6.5
作者：
Liu J;Ehmsen KT;Heyer WD;Morrical SW
通讯作者：
Morrical SW
影响因子：
3.8
作者：
Ede, Christopher;Rudolph, Christian J.;Kramer, Wilfried
通讯作者：
Kramer, Wilfried
DOI：
10.1073/pnas.121009398
发表时间：
2001-07-17
影响因子：
11.1
作者：
Jones, CE;Mueser, TC;Nossal, NG
通讯作者：
Nossal, NG
影响因子：
10.5
作者：
Lydeard, John R.;Lipkin-Moore, Zachary;Haber, James E.
通讯作者：
Haber, James E.
DOI：
10.1007/978-0-387-92808-1_10
发表时间：
2011-01-01
期刊：
BIOPHYSICS OF DNA- PROTEIN INTERACTIONS: FROM SINGLE MOLECULES TO BIOLOGICAL SYSTEMS
影响因子：
--
作者：
Liu, Jie;Morrical, Scott W.
通讯作者：
Morrical, Scott W.