Age dependency of risk factors for cognitive decline.
Age dependency of risk factors for cognitive decline.
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DOI：
10.1186/s12877-018-0876-2
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发表时间：
2018-08-20
期刊：
影响因子：
4.1
通讯作者：
Visser PJ
中科院分区：
文献类型：
--
作者：
Legdeur N;Heymans MW;Comijs HC;Huisman M;Maier AB;Visser PJ
认知能力下降的危险因素可能取决于实际年龄。该研究的目的是探讨基线年龄为 55-85 岁的认知健康受试者认知能力下降的危险因素的年龄依赖性。我们纳入了来自阿姆斯特丹纵向衰老研究 (LASA) 的 2527 名认知健康受试者。中位随访时间为 9.1 年（IQR：3.2-19.0）年。使用样条回归分析测试遗传和心血管危险因素、抑郁症状、炎症标志物和生活方式危险因素与 MMSE 和记忆功能下降的关联。受试者基线时平均年龄为 70.1 (SD 8.8)。基于样条回归模型，我们将样本分为三个年龄组：≤70 岁（年轻）、> 70–80 岁（老年）和 > 80 岁（最年长）。低密度脂蛋白胆固醇、同型半胱氨酸、高血压、中风病史、抑郁症状、白细胞介素6、α1-抗胰凝乳蛋白酶、饮酒和吸烟与认知能力下降的关系在不同年龄组之间存在显着差异。一般来说，与年轻人和老年群体相比，这些危险因素的存在与年龄最大的群体的认知能力下降较少相关。各种危险因素对认知能力下降的负面影响随着年龄的增长而减弱。流行病学因素（例如在随访期间选择更健康的受试者）以及危险因素的特定特征（例如在高血压情况下确保脑血流量）的结合解释了这种在较高年龄时相关性减弱的原因。在应用预防策略以避免认知能力下降时，重要的是要考虑到这些年龄差异。本文的在线版本 (10.1186/s12877-018-0876-2) 包含补充材料，可供授权用户使用。
Risk factors for cognitive decline might depend on chronological age. The aim of the study was to explore the age dependency of risk factors for cognitive decline in cognitively healthy subjects aged 55–85 years at baseline. We included 2527 cognitively healthy subjects from the Longitudinal Aging Study Amsterdam (LASA). Median follow-up was 9.1 (IQR: 3.2–19.0) years. The association of genetic and cardiovascular risk factors, depressive symptoms, inflammation markers and lifestyle risk factors with decline in MMSE and memory function was tested using spline regression analyses. Subjects were on average 70.1 (SD 8.8) years old at baseline. Based on a spline regression model, we divided our sample in three age groups: ≤70 years (young-old), > 70–80 years (old) and > 80 years (oldest-old). The association of LDL cholesterol, homocysteine, hypertension, history of stroke, depressive symptoms, interleukin-6, a1-antichymotrypsin, alcohol use and smoking with cognitive decline significantly differed between the age groups. In general, the presence of these risk factors was associated with less cognitive decline in the oldest-old group compared to the young-old and old group. The negative effect of various risk factors on cognitive decline decreases with higher age. A combination of epidemiological factors, such as the selection towards healthier subjects during follow-up, but also risk factor specific features, for example ensuring the cerebral blood flow in case of hypertension, explain this diminished association at higher age. It is important to take these age differences into account when applying preventive strategies to avert cognitive decline. The online version of this article (10.1186/s12877-018-0876-2) contains supplementary material, which is available to authorized users.
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影响因子：
6.9
作者：
Brailean A;Aartsen MJ;Muniz-Terrera G;Prince M;Prina AM;Comijs HC;Huisman M;Beekman A
通讯作者：
Beekman A
DOI：
10.1016/j.jalz.2016.09.007
发表时间：
2017-02
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
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作者：
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