Suppressive Role of Lactoferrin in Overweight-Related Female Fertility Problems.
Suppressive Role of Lactoferrin in Overweight-Related Female Fertility Problems.
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乳铁蛋白在超重相关女性生育问题中的抑制作用
DOI：
10.3390/nu14050938
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发表时间：
2022-02-22
期刊：
影响因子：
5.9
通讯作者：
Kawano N
中科院分区：
文献类型：
--
作者：
Sato B;Kanai S;Sakaguchi D;Yajima K;Matsumoto Y;Morohoshi K;Kagaya S;Izumo N;Ichinose M;Kang W;Miyado M;Miyado K;Kawano N
分泌性糖蛋白乳铁蛋白（LF）被认为是改善超重，无论非遗传或遗传机制。虽然母亲超重是后代生长的一个关键预测因素，但LF对超重和肥胖母亲生育问题的疗效仍然未知。为了解决这个问题，我们通过分析超重小鼠（癌症研究所（ICR）高脂饮食小鼠; HF小鼠）和肥胖小鼠（患有II型糖尿病的瘦素缺陷小鼠; ob/ob小鼠）来检查LF摄入的影响。测量血浆胰岛素、瘦素、葡萄糖和胆固醇水平，并进行热成像和组织学分析。HF雌性的窝仔数由于流产而减少，这通过LF摄入而逆转。此外，LF摄入抑制其后代的超重患病率。母体血液的成分分析表明，HF女性及其后代的葡萄糖浓度通过LF摄入而正常化，这进一步标准化了胰岛素的浓度，但不是瘦素。LF摄入不能逆转ob/ob小鼠的雌性不育，尽管它们的肥胖和子宫功能得到部分改善。我们的研究结果表明，LF通过加强由于热量过剩而超重的女性的卵巢和子宫功能来上调女性生育力。
The secretory glycoprotein lactoferrin (LF) is suggested to ameliorate overweight regardless of non-genetic or genetic mechanisms. Although maternal overweight represents a key predictor of offspring growth, the efficacy of LF on fertility problems in overweight and obese mothers remains unknown. To address this issue, we examined the effect of LF ingestion by analyzing overweight mice (Institute of Cancer Research (ICR) mice with high-fat diets; HF mice) and obese mice (leptin-deficient mice with type II diabetes; ob/ob mice). Plasma insulin, leptin, glucose, and cholesterol levels were measured, and thermal imaging and histological analysis were employed. The litter size of HF females was reduced due to miscarriage, which was reversed by LF ingestion. In addition, LF ingestion suppressed overweight prevalence in their offspring. The component analysis of the maternal blood demonstrated that glucose concentration in both HF females and their offspring was normalized by LF ingestion, which further standardized the concentration of insulin, but not leptin. LF ingestion was unable to reverse female infertility in ob/ob mice, although their obesity and uterine function were partially improved. Our results indicate that LF upregulates female fertility by reinforcing ovarian and uterine functions in females that are overweight due to caloric surplus.
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DOI：
10.1152/ajpendo.00363.2015
发表时间：
2016-06-01
影响因子：
5.1
作者：
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Calderon, Iracema M. P.