Two unlike cousins: Candida albicans and C. glabrata infection strategies.
Two unlike cousins: Candida albicans and C. glabrata infection strategies.
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DOI：
10.1111/cmi.12091
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发表时间：
2013-05
影响因子：
3.4
通讯作者：
Hube B
中科院分区：
文献类型：
--
作者：
Brunke S;Hube B
白念珠菌和光滑念珠菌是人类最常见的两种致病酵母菌，但它们在系统发育、遗传和表型上存在很大差异。本文对白念珠菌和光滑念珠菌附着和侵入宿主、获取营养物质和逃避宿主免疫反应的策略进行了比较和对比。尽管他们的战略有一些共同的基本概念，但在结果上却大相径庭。白念珠菌遵循一种积极的策略来颠覆宿主的反应并获得生存所需的营养物质，而光滑念珠菌似乎已经进化出一种基于隐形、逃避和坚持的策略，而不会在小鼠模型中造成严重损害。然而，这两种真菌都成功地作为人类的共生体和病原体。了解这些策略将有助于找到抗击念珠菌和真菌感染的新方法。
Candida albicans and C. glabrata are the two most common pathogenic yeasts of humans, yet they are phylogenetically, genetically and phenotypically very different. In this review, we compare and contrast the strategies of C. albicans and C. glabrata to attach to and invade into the host, obtain nutrients and evade the host immune response. Although their strategies share some basic concepts, they differ greatly in their outcome. While C. albicans follows an aggressive strategy to subvert the host response and to obtain nutrients for its survival, C. glabrata seems to have evolved a strategy which is based on stealth, evasion and persistence, without causing severe damage in murine models. However, both fungi are successful as commensals and as pathogens of humans. Understanding these strategies will help in finding novel ways to fight Candida, and fungal infections in general.
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影响因子：
9.2
作者：
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通讯作者：
Casadevall, Arturo
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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