Associations between single nucleotide polymorphisms in cellular viral receptors and attachment factor-related genes and humoral immunity to rubella vaccination.
Associations between single nucleotide polymorphisms in cellular viral receptors and attachment factor-related genes and humoral immunity to rubella vaccination.
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DOI：
10.1371/journal.pone.0099997
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Poland GA
中科院分区：
文献类型：
--
作者：
Haralambieva IH;Lambert ND;Ovsyannikova IG;Kennedy RB;Larrabee BR;Pankratz VS;Poland GA
病毒附着和细胞进入宿主因子对于病毒复制、发病机制以及感染和/或接种后免疫应答的产生和维持是重要的，并且是疫苗诱导的免疫的合理遗传调节剂。在候选基因研究中使用tag-SNP方法，我们在两个独立的研究队列中评估了选定的细胞表面受体基因、附着因子相关基因以及沿着其他免疫基因在风疹活疫苗接种后免疫应答变异的遗传控制中的作用。我们的分析揭示了PVR、PVRL 2、CD 209/DC-SIGN、RARB、MOG、IL 6和其他免疫功能相关基因中的遗传变异与接种后风疹特异性中和抗体之间存在多重关联的证据（Meta p值<0.05）。我们的研究结果表明，多个SNPs的基因参与细胞粘附，病毒附着，和病毒进入，以及其他参与信号和/或免疫反应调节的基因，在调节体液免疫反应后，活风疹疫苗接种的作用。
Viral attachment and cell entry host factors are important for viral replication, pathogenesis, and the generation and sustenance of immune responses after infection and/or vaccination, and are plausible genetic regulators of vaccine-induced immunity. Using a tag-SNP approach in candidate gene study, we assessed the role of selected cell surface receptor genes, attachment factor-related genes, along with other immune genes in the genetic control of immune response variations after live rubella vaccination in two independent study cohorts. Our analysis revealed evidence for multiple associations between genetic variants in the PVR, PVRL2, CD209/DC-SIGN, RARB, MOG, IL6 and other immune function-related genes and rubella-specific neutralizing antibodies after vaccination (meta p-value <0.05). Our results indicate that multiple SNPs from genes involved in cell adhesion, viral attachment, and viral entry, as well as others in genes involved in signaling and/or immune response regulation, play a role in modulating humoral immune responses following live rubella vaccination.
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影响因子：
3.2
作者：
Dhiman, Neelam;Haralambieva, Iana H.;Kennedy, Richard B.;Vierkant, Robert A.;O'Byrne, Megan M.;Ovsyannikova, Inna G.;Jacobson, Robert M.;Poland, Gregory A.
通讯作者：
Poland, Gregory A.
影响因子：
5.3
作者：
Kennedy RB;Ovsyannikova IG;Pankratz VS;Haralambieva IH;Vierkant RA;Jacobson RM;Poland GA
通讯作者：
Poland GA
影响因子：
5.9
作者：
Backovic M;Rey FA
通讯作者：
Rey FA
影响因子：
5.5
作者：
Haralambieva, Iana H.;Ovsyannikova, Inna G.;Kennedy, Richard B.;Vierkant, Robert A.;Pankratz, V. Shane;Jacobson, Robert M.;Poland, Gregory A.
通讯作者：
Poland, Gregory A.
影响因子：
3.7
作者：
Kamran N;Takai Y;Miyoshi J;Biswas SK;Wong JS;Gasser S
通讯作者：
Gasser S