Limitation of stunning in dog myocardium by nucleoside and nucleotide mixture, OG-VI.
Limitation of stunning in dog myocardium by nucleoside and nucleotide mixture, OG-VI.
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核苷和核苷酸混合物 OG-VI 对狗心肌击晕的限制。
DOI：
10.1016/s0899-9007(96)00377-2
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发表时间：
1997
期刊：
影响因子：
4.4
通讯作者：
H. Kohri
中科院分区：
文献类型：
--
作者：
K. Ichihara;S. Kano;K. Satoh;T. Nakai;T. Fukutomi;Y. Okazaki;H. Kohri
OG-VI是由30 mM肌苷、30 mM 5′-鸟苷酸钠、30 mM胞苷、22.5 mM尿苷和7.5 mM胸苷组成的溶液，预期用于全胃肠外营养。我们研究了OG-VI对犬缺血再灌注（心肌顿抑）期间心肌收缩功能障碍的影响。对戊巴比妥麻醉的狗进行20分钟左前降支冠状动脉结扎，然后再灌注30分钟。在缺血前30 min开始输注生理盐水、OG-VI或其组分[肌苷和5′-鸟苷酸钠混合物（IG）和胞苷、尿苷和胸苷混合物（CUT）]或5-氨基-4-咪唑甲酰胺核苷（AICAR）0.1 mL · kg-1· min-1。通过超声测量法测定收缩功能，并以节段缩短率（%SS）进行评估。%SS在缺血后明显下降，再灌注后恢复至缺血前水平，但恢复不完全。OG-VI和IG几乎完全恢复%SS，AICAR恢复程度较低; CUT无效。OG-VI在1 mg · kg-1腺苷A1受体拮抗剂8-环戊基-1，3-二丙基黄嘌呤（DPCPX）存在下，对顿抑心肌仍有保护作用。总之，输注OG-VI改善了顿抑心肌的心肌收缩功能障碍。这种作用比其成分和AICAR更有效。腺苷A1受体不参与此机制。
OG-VI is a solution composed of 30 mM inosine, 30 mM sodium 5′-guanylate, 30 mM cytidine, 22.5 mM uridine, and 7.5 mM thymidine, expecting to use for total parenteral nutrition. We examined the effect of OG-VI on myocardial contractile dysfunction during reperfusion after ischemia (myocardial stunning) in dogs. Pentobarbital-anesthetized dogs were subjected to 20-min left anterior descending coronary artery ligation followed by 30-min reperfusion. Saline, OG-VI or its constituents [inosine and sodium 5′-guanylate mixture (IG), and cytidine, uridine, and thymidine mixture (CUT)], or 5-amino-4-imidazole carboxamide riboside (AICAr) was infused at 0.1 mL · kg−1· min−1, starting 30 min before the ischemia. The contractile function was determined by ultrasonometry and assessed as % segment shortening (%SS). %SS was markedly decreased by ischemia, and returned toward pre-ischemic level after reperfusion, although the recovery was incomplete. The %SS was almost completely recovered by OG-VI and IG, and to a lesser extent by AICAr; CUT was ineffective. In the presence of 1 mg · kg−1of 8-cyclopentyl-1,3-dipropylxanthine (DPCPX, a selective adenosine A1receptor antagonist), cardioprotective effect of OG-VI on stunned myocardium was still observed. In conclusion, infusion of OG-VI improved myocardial contractile dysfunction in stunned myocardium. This effect was more potent than its constituents and AICAr. Adenosine A1receptors are not involved in the mechanism.
阿卡地辛通过腺苷介导的机制减少心肌梗塞面积。
DOI：
--
发表时间：
1995
期刊：
Cardiovascular research.
影响因子：
--
作者：
Zhao,ZQ;Williams,MW;Sato,H;Hudspeth,DA;McGee,DS;Vinten-Johansen,J;VanWylen,DG
通讯作者：
VanWylen,DG
使用嘌呤从头合成的前体加速犬缺血后心肌中 ATP 和 GTP 库的补充。
影响因子：
20.1
作者：
Swain,JL;Hines,JJ;Sabina,RL;Holmes,EW
通讯作者：
Holmes,EW