Possible association between suicide committed under influence of ethanol and a variant in the AUTS2 gene.
Possible association between suicide committed under influence of ethanol and a variant in the AUTS2 gene.
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DOI：
10.1371/journal.pone.0057199
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Płoski R
中科院分区：
文献类型：
--
作者：
Chojnicka I;Gajos K;Strawa K;Broda G;Fudalej S;Fudalej M;Stawiński P;Pawlak A;Krajewski P;Wojnar M;Płoski R
AUTS2中的rs6943555已被证明可以调节乙醇的消耗。我们推测rs6943555可能与完全自杀有关。我们使用实时TaqMan等位基因歧视分析技术对625例自杀完成者和3861例对照组的rs6943555进行了基因分型。所有人都是波兰高加索人。我们发现自杀与rs6943555A等位基因有关(OR = 1.17，P = 0.018用于等位基因比较，OR = 1.24，P = 0.013用于显性遗传，OR = 1.18，P = 0.020用于共显性遗传模式)。在调整了年龄和性别后，这种相关性仍然显著(共同主导：P = 0.002，主导模式：P = 0.001)。根据血液酒精浓度(BAC≤20 mg/dl和BAC&Gt；20 mg/dl)对自杀病例进行分层后，只有在酒精影响下自杀的病例(共同显性：或 = 1.37，P = 0.004和显性模式：或 = 1.45，P = 0.006)，这种关联仍然显著。为了验证这一发现，我们对另一组132例病例进行了基因分型。我们复制了rs6943555A等位基因与乙醇影响下自杀的关联(等位基因比较：OR = 1.55，P = 0.023；共显性：OR = 1.54，P = 0.031；显性模式：OR = 1.84，P = 0.015)。对合并自杀病例进行分析，发现rs6943555A等位基因不仅与对照组(等位基因OR = 1.41，P = 0.00029)相关，而且与合并自杀病例(N≤20 mg/dl)(N = 449，等位基因OR = 1.33，P = 0.019)相关。在我们的研究中，rs6943555A等位基因与死前饮用酒精后自杀有关。Rs6943555A等位基因可能与酒精的不良情绪反应有关，这可能解释了普通人群中较低的饮酒量以及在酒精影响下自杀的倾向。
rs6943555 in AUTS2 has been shown to modulate ethanol consumption. We hypothesized that rs6943555 might be associated with completed suicide. We genotyped rs6943555 in 625 completed suicides and 3861 controls using real-time TaqMan Allelic Discrimination Assay. All individuals were Polish Caucasians. We detected an association between suicide and rs6943555 A allele (OR = 1.17, P = 0.018 for allelic comparison, OR = 1.24, P = 0.013 for dominant, and OR = 1.18, P = 0.020 for co-dominant model of inheritance). The association remained significant after adjusting for age and gender (co-dominant: P = 0.002 and dominant model: P = 0.001). After stratifying suicides according to blood ethanol concentration (BAC≤ 20 mg/dl and BAC > 20 mg/dl) the association remained significant only for cases who committed suicide under influence of alcohol (co-dominant: OR = 1.37, P = 0.004 and dominant model: OR = 1.45, P = 0.006). To validate this finding we genotyped another cohort of 132 cases. We reproduced the association between rs6943555 A allele and suicide under influence of ethanol (allelic comparison: OR = 1.55, P = 0.023; co-dominant : OR = 1.54, P = 0.031; dominant model: OR = 1.84, P = 0.015). Analyzing pooled suicides with BAC >20 mg/dl (N = 300) we found the association of rs6943555 A allele not only vs. controls (allelic OR = 1.41, P = 0.00029) but also vs. cases with BAC ≤ 20 mg/dl (N = 449, allelic OR = 1.33, P = 0.019). In our study rs6943555 A allele is associated with suicide committed after drinking ethanol shortly before death. The rs6943555 A allele may be linked to adverse emotional reaction to ethanol, which could explain the association with lower consumption in general population as well as the predisposition to suicide under influence of ethanol.
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当解决方案是问题的一部分时：在老年人自杀案中解决问题。
影响因子：
4
作者：
Gibbs, Lawrence M.;Dombrovski, Alexandre Y.;Morse, Jennifer;Siegle, Greg J.;Houck, Patricia R.;Szanto, Katalin
通讯作者：
Szanto, Katalin
影响因子：
4.4
作者：
Kim, Sanghyeon;Choi, Kwong-Ho;Baykiz, Ali Fuat;Gershenfeld, Howard K
通讯作者：
Gershenfeld, Howard K
DOI：
10.1111/j.1365-2788.2009.01204.x
发表时间：
2009-11-01
影响因子：
3.6
作者：
Embregts, P.;van Nieuwenhuijzen, M.
通讯作者：
van Nieuwenhuijzen, M.
DOI：
10.1002/ajmg.c.30042
发表时间：
2005-02-15
影响因子：
3.1
作者：
Brent, DA;Mann, JJ
通讯作者：
Mann, JJ
DOI：
10.1016/j.gep.2009.11.005
发表时间：
2010-01
期刊：
Gene expression patterns : GEP
影响因子：
--
作者：
Bedogni F;Hodge RD;Nelson BR;Frederick EA;Shiba N;Daza RA;Hevner RF
通讯作者：
Hevner RF