Changes in Circulating Levels of Calcitonin Gene-Related Peptide and Nitric Oxide Metabolites in Septic Patients during Direct Hemoperfusion with Polymyxin B-Immobilized Fiber
Changes in Circulating Levels of Calcitonin Gene-Related Peptide and Nitric Oxide Metabolites in Septic Patients during Direct Hemoperfusion with Polymyxin B-Immobilized Fiber
复制标题
多粘菌素B固定化纤维直接血液灌流脓毒症患者降钙素基因相关肽和一氧化氮代谢物循环水平的变化
DOI：
10.1159/000070696
复制
发表时间：
2003
影响因子：
3
通讯作者：
H. Katayama
中科院分区：
文献类型：
--
作者：
Tomoharu Shimizu;K. Hanasawa;T. Tani;Y. Endo;Y. Kurumi;T. Ikeda;N. Fujita;H. Morita;H. Imaizumi;Takashi Sato;H. Katayama
背景/目的：本研究评价了多粘菌素B固定纤维（PMX）治疗中血流动力学改善的机制。方法：对15例合并内毒素血症和（或）革兰阴性菌感染的脓毒症患者进行PMX治疗。测定血浆降钙素基因相关肽（CGRP）和一氧化氮代谢产物的浓度。结果：治疗前CGRP和一氧化氮代谢产物明显高于健康对照组。CGRP与舒张压呈显著负相关，与脓毒症严重程度评分和衰竭器官数呈正相关。PMX治疗后即刻和24 h的收缩压、舒张压和体循环血管阻力指数均显著升高。CGRP在治疗后24 h显著下降。相反，一氧化氮代谢产物没有显著变化。结论：PMX治疗可改善脓毒症患者的血流动力学参数，且CGRP随脓毒症严重程度的增加而升高。我们的结论是CGRP水平的降低可能与PMX治疗引起的血流动力学改善有关。
Background/Aims: This study evaluated the mechanism of hemodynamic improvement in polymyxin B-immobilized fiber (PMX) treatment. Methods: Fifteen septic patients with endotoxemia and/or gram negative infection were treated with PMX. Plasma concentrations of calcitonin gene-related peptide (CGRP) and nitric oxide metabolites were measured. Results: CGRP and nitric oxide metabolites before treatment were significantly higher than in healthy controls. CGRP had a significantly inverse correlation with diastolic blood pressure and a positive correlation with the Septic Severity Score and the number of failed organs. Systolic and diastolic blood pressure and systemic vascular resistance index increased significantly both immediately after and 24 h after PMX treatment. CGRP decreased significantly 24 h after the treatment. In contrast, there were no significant changes in nitric oxide metabolites. Conclusion: PMX treatment improved hemodynamic parameters in septic patients, and CGRP increased with increasing severity of sepsis. We conclude that a decrease in CGRP levels may be related to hemodynamic improvement resulting from PMX treatments.
影响因子：
2.9
作者：
GREEN, LC;WAGNER, DA;TANNENBAUM, SR
通讯作者：
TANNENBAUM, SR