Bronchial provocation testing with dry powder mannitol in children with cystic fibrosis

Bronchial provocation testing with dry powder mannitol in children with cystic fibrosis
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囊性纤维化儿童干粉甘露醇支气管激发试验

DOI:
10.1002/ppul.20903
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发表时间:
2008
影响因子:
3.1
通讯作者:
A. Bush
A. Bush
中科院分区:
医学3区
文献类型:
--
作者:
C. Minasian;C. Wallis;C. Metcalfe;A. Bush

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最近,人们对干粉吸入甘露醇作为囊性纤维化(CF)患者的治疗剂感兴趣。它已被证明可以通过再水化呼吸道来增加粘液纤毛清除(MCC)。到目前为止,还没有专门针对CF儿童的研究,考察干粉甘露醇对呼吸道的影响。本研究的目的是确定吸入性甘露醇在CF儿童中的急性耐受性。
There has been recent interest in dry powder inhaled mannitol as a therapeutic agent in patients with cystic fibrosis (CF). It is has been shown to increase mucociliary clearance (MCC) by rehydrating the airway. To date there have been no studies exclusively in children with CF examining the effect of dry powder mannitol on the airways. The aim of this study was to determine acute tolerability of inhaled mannitol in children with CF.
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