Associations between muscle-related cytokines and selected patient outcomes in the ICU.
Associations between muscle-related cytokines and selected patient outcomes in the ICU.
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DOI：
10.1177/1099800414532709
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发表时间：
2015-03
影响因子：
2.5
通讯作者：
Gordon N
中科院分区：
文献类型：
--
作者：
Winkelman C;Johnson KD;Gordon N
骨骼肌收缩产生的系统细胞因子可能影响重症监护病房（ICU）获得性虚弱的发病和严重程度。本研究的目的是测定接受机械通气bbbb48小时患者的血清白细胞介素(IL)-8、IL-15和肿瘤坏死因子-α (TNF-α)水平，并研究这些肌因子与患者谵妄、肌肉力量、日常生活活动（ADLs）、机械通气持续时间和ICU住院时间的关系。在这项探索性、重复测量的介入研究中，36名参与者在ICU中证明生理稳定≥4小时后，使用既定的早期渐进式活动方案，每天进行一次20分钟的床上或床下活动。从入组当天开始，连续3天抽取血样，进行血清细胞因子定量。与正常健康成人相比，参与者的IL-8、IL-15和TNF-α变化很大，且持续升高。约1/3的参与者在出院时出现明显的肌肉无力。活动后平均血清IL-8值的重复值仅与ICU出院后的ADL显著相关。与活动后平均IL-15或TNF-α血清值和结果的重复值无显著关联。结果为探索血清IL-8和IL-15升高对肌肉健康的潜在影响以及TNF-α对肌肉损伤的潜在影响提供了初步数据，包括计算未来研究所需样本量的效应量。
Systemic cytokines produced by contracting skeletal muscles may affect the onset and severity of intensive care unit (ICU)-acquired weakness after critical illness. The purpose of this research was to determine the serum levels of interleukin (IL)-8, IL-15, and tumor necrosis factor-α (TNF-α) among patients receiving mechanical ventilation for >48 hr and examine the relationships of these myokines to outcomes of patient delirium, muscle strength, activities of daily living (ADLs), duration of mechanical ventilation, and length of ICU stay. In this exploratory, repeated-measures interventional study, the 36 participants received 20 min of once-daily in-bed or out-of-bed activity using an established early progressive mobility protocol after physiologic stability had been demonstrated for ≥4 hr in the ICU. Blood samples were drawn on 3 consecutive days, beginning on the day of study enrollment, for serum cytokine quantification. IL-8, IL-15, and TNF-α were highly variable and consistently elevated in participants compared to normal healthy adults. About 1/3 of participants were positive for significant muscle weakness at discharge from ICU. Repeated values of mean postactivity IL-8 serum values were significantly associated only with ADL following ICU discharge. There were no significant associations with repeated values of mean postactivity IL-15 or TNF-α serum values and outcomes. Results provide preliminary data for exploring the potential effects of elevated serum values IL-8 and IL-15 in muscle health and TNF-α for muscle damage, including effect sizes to calculate the sample sizes needed for future studies.
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DOI：
10.1097/aco.0b013e3283445382
发表时间：
2011-04
期刊：
Current opinion in anaesthesiology
影响因子：
--
作者：
Banerjee A;Girard TD;Pandharipande P
通讯作者：
Pandharipande P
影响因子：
3.8
作者：
Dirriopoulou, Ioanna;Orfanos, Stylianos;Armaganidis, Apostolos
通讯作者：
Armaganidis, Apostolos
影响因子：
8.8
作者：
Ely, EW;Margolin, R;Inouye, SK
通讯作者：
Inouye, SK
影响因子：
2.5
作者：
Fan, Eddy
通讯作者：
Fan, Eddy
影响因子：
2.7
作者：
Frydelund-Larsen, Lone;Penkowa, Milena;Pedersen, Bente Klarlund
通讯作者：
Pedersen, Bente Klarlund