Impact of neurocognition on social and role functioning in individuals at clinical high risk for psychosis.
Impact of neurocognition on social and role functioning in individuals at clinical high risk for psychosis.
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DOI：
10.1176/appi.ajp.2011.10081209
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发表时间：
2011-08
期刊：
影响因子：
--
通讯作者：
Cornblatt BA
中科院分区：
文献类型：
--
作者：
Carrión RE;Goldberg TE;McLaughlin D;Auther AM;Correll CU;Cornblatt BA
精神分裂症患者的认知缺陷已得到充分证明，并已被证明会损害生活质量并损害日常功能。最近对青少年和年轻人在发展为精神病的高风险的研究表明，神经认知障碍是可检测的精神病症状发作之前。然而，目前尚不清楚认知障碍如何影响精神病发作前的功能。作者评估了处于精神病临床高风险的青少年的认知障碍，并检查了其对社会和角色功能的影响。127名寻求治疗的精神病临床高危患者和一组80名健康对照受试者的样本被确定并招募用于识别和预防计划的研究。在基线时，参与者接受了全面的神经认知电池以及社会和角色功能的评估。相对于健康对照组，临床高危患者在处理速度、言语记忆、执行功能、工作记忆、视觉空间处理、运动速度、持续注意力和语言领域表现出显著的损伤。临床高风险患者在基线时也表现出社会和角色功能受损。在阳性症状减弱的患者中，处理速度与基线时的社会和角色功能有关。这些研究结果表明，认知和功能障碍是可检测到的患者在临床高风险的精神病发作前的精神病和处理速度似乎是一个重要的认知功能差的预测。
Cognitive deficits have been well documented in schizophrenia and have been shown to impair quality of life and to compromise everyday functioning. Recent studies of adolescents and young adults at high risk for developing psychosis show that neurocognitive impairments are detectable before the onset of psychotic symptoms. However, it remains unclear how cognitive impairments affect functioning before the onset of psychosis. The authors assessed cognitive impairment in adolescents at clinical high risk for psychosis and examined its impact on social and role functioning. A sample of 127 treatment-seeking patients at clinical high risk for psychosis and a group of 80 healthy comparison subjects were identified and recruited for research in the Recognition and Prevention Program. At baseline, participants were assessed with a comprehensive neurocognitive battery as well as measures of social and role functioning. Relative to healthy comparison subjects, clinical high-risk patients showed significant impairments in the domains of processing speed, verbal memory, executive function, working memory, visuospatial processing, motor speed, sustained attention, and language. Clinical high-risk patients also displayed impaired social and role functioning at baseline. Among patients with attenuated positive symptoms, processing speed was related to social and role functioning at baseline. These findings demonstrate that cognitive and functional impairments are detectable in patients at clinical high risk for psychosis before the onset of psychotic illness and that processing speed appears to be an important cognitive predictor of poor functioning.
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