Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol.
Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol.
复制标题
DOI：
10.1136/bmjopen-2020-048317
复制
发表时间：
2021-03-17
期刊：
影响因子：
2.9
通讯作者：
COVID-LIV Study Group
中科院分区：
文献类型：
--
作者：
Setiabudi W;Hungerford D;Subramaniam K;Vaselli NM;Shaw VE;Wilton M;Vivancos R;Aston S;Platt G;Moitt T;Jones AP;Gabbay M;Buchan I;Carrol ED;Iturriza-Gomara M;Solomon T;Greenhalf W;Naisbitt DJ;Adams ER;Cunliffe NA;Turtle L;French N;COVID-LIV Study Group
新冠肺炎的出现和迅速传播造成了广泛而灾难性的公共卫生和经济影响，要求各国政府限制社会活动，以减少疾病的传播。家庭传播在SARS-CoV-2人群传播中的作用，以及宿主免疫在限制传播中的作用，人们知之甚少。本文描述了一项对英国利物浦市地区一组家庭进行前瞻性观察研究的方案，该方案研究了SARS-CoV-2在家庭成员之间的传播，以及对感染的免疫反应如何随着时间的推移而变化。利物浦城地区的家庭成员以前从未用核酸扩增测试检测出SARS-CoV-2呈阳性，这些家庭被跟踪调查，最初为期12周。参与者被要求每周提供自咽和鼻拭子，并记录他们的活动和症状的存在。测量新冠肺炎的感染率和家庭二次发病率。SARS-CoV-2的传播将根据一系列人口和行为变量进行调查。在多个时间点采集血液和粪便样本，分别评估对SARS-CoV-2感染的免疫反应和SARS-CoV-2粪便脱落的患病率和危险因素。该研究已获得国家卫生服务研究伦理委员会的批准；REC参考文献：20/HRA/2297，IRAS编号：283 464。结果将通过科学会议和同行评议的开放获取出版物传播。调查结果的报告也将与与会者分享。这项研究将量化SARS-CoV-2的家庭传播规模和决定因素。此外，还将分析感染前和感染不同阶段期间的免疫反应，以加深对感染严重程度的免疫反应范围的了解。
The emergence and rapid spread of COVID-19 have caused widespread and catastrophic public health and economic impact, requiring governments to restrict societal activity to reduce the spread of the disease. The role of household transmission in the population spread of SARS-CoV-2, and of host immunity in limiting transmission, is poorly understood. This paper describes a protocol for a prospective observational study of a cohort of households in Liverpool City Region, UK, which addresses the transmission of SARS-CoV-2 between household members and how immunological response to the infection changes over time. Households in the Liverpool City Region, in which members have not previously tested positive for SARS-CoV-2 with a nucleic acid amplification test, are followed up for an initial period of 12 weeks. Participants are asked to provide weekly self-throat and nasal swabs and record their activity and presence of symptoms. Incidence of infection and household secondary attack rates of COVID-19 are measured. Transmission of SARS-CoV-2 will be investigated against a range of demographic and behavioural variables. Blood and faecal samples are collected at several time points to evaluate immune responses to SARS-CoV-2 infection and prevalence and risk factors for faecal shedding of SARS-CoV-2, respectively. The study has received approval from the National Health Service Research Ethics Committee; REC Reference: 20/HRA/2297, IRAS Number: 283 464. Results will be disseminated through scientific conferences and peer-reviewed open access publications. A report of the findings will also be shared with participants. The study will quantify the scale and determinants of household transmission of SARS-CoV-2. Additionally, immunological responses before and during the different stages of infection will be analysed, adding to the understanding of the range of immunological response by infection severity.
登录
查看更多内容
影响因子：
2.9
作者：
Giebel, Clarissa;McIntyre, Jason Cameron;Barr, Ben
通讯作者：
Barr, Ben
影响因子：
158.5
作者：
Boulware, David R.;Pullen, Matthew F.;Hullsiek, Kathy H.
通讯作者：
Hullsiek, Kathy H.
影响因子：
3.7
作者：
Koh WC;Naing L;Chaw L;Rosledzana MA;Alikhan MF;Jamaludin SA;Amin F;Omar A;Shazli A;Griffith M;Pastore R;Wong J
通讯作者：
Wong J
DOI：
10.1016/j.remle.2020.05.007
发表时间：
2020-07-15
期刊：
Spanish Journal of Legal Medicine
影响因子：
--
作者：
Fernández-Rodríguez A;Casas I;Culebras E;Morilla E;Cohen MC;Alberola J
通讯作者：
Alberola J
影响因子：
13.8
作者：
Madewell ZJ;Yang Y;Longini IM Jr;Halloran ME;Dean NE
通讯作者：
Dean NE