Sox12 promotes T reg differentiation in the periphery during colitis.
Sox12 promotes T reg differentiation in the periphery during colitis.
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DOI：
10.1084/jem.20172082
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发表时间：
2018-10-01
期刊：
影响因子：
--
通讯作者：
Nakajima H
中科院分区：
文献类型：
--
作者：
Tanaka S;Suto A;Iwamoto T;Kageyama T;Tamachi T;Takatori H;Suzuki K;Hirose K;Ohara O;Lefebvre V;Nakajima H
Tanaka等表明，Sox 12是SoxC家族的成员，在T细胞中由TCR-NFAT信号传导诱导，结合Foxp 3启动子并驱动其转录，并在结肠炎期间诱导外周中T reg细胞的分化。外周诱导的调节性T（pT reg）细胞在调节肠道炎症中起着不可或缺的作用;然而，在炎症条件下pT reg细胞分化的机制在很大程度上仍然未知。在这里，我们表明，表达的Sox 12，SoxC家族的成员，显着诱导T reg细胞在结肠炎小鼠。我们还显示TCR-NFAT信号传导诱导CD 4 + T细胞中的Sox 12表达。虽然Sox 12不是胸腺来源的T reg（tT reg）细胞的发育所必需的，但在过继转移结肠炎模型中，Sox 12参与了炎症条件下pT reg细胞的发育。此外，我们发现，即使在不存在TGF-β或IL-2的情况下，Sox 12的强制表达也足以促进Foxp 3在CD 4 + T细胞中的表达，并且Sox 12结合Foxp 3启动子并驱动其转录。这些结果表明，TCR-NFAT信号传导部分通过Sox 12诱导诱导结肠炎小鼠中pT reg细胞的发育。
Tanaka et al. show that Sox12, a member of SoxC family, is induced by TCR-NFAT signaling in T cells, binds to the Foxp3 promoter and drives its transcription, and induces the differentiation of T reg cells in the periphery during colitis. Peripherally induced regulatory T (pT reg) cells play indispensable roles in regulating gut inflammation; however, the mechanism underling the differentiation of pT reg cells under inflammatory conditions remains largely unknown. Here, we show that the expression of Sox12, a member of SoxC family, is significantly induced in T reg cells in colitic mice. We also show that TCR–NFAT signaling induces Sox12 expression in CD4+ T cells. Although Sox12 is not required for the development of thymus-derived T reg (tT reg) cells, Sox12 is involved in the development of pT reg cells under inflammatory conditions in an adoptive transfer colitis model. Moreover, we found that enforced expression of Sox12 is sufficient to promote Foxp3 expression in CD4+ T cells even in the absence of TGF-β or IL-2 and that Sox12 binds to Foxp3 promoter and drives its transcription. These results suggest that TCR-NFAT signaling induces the development of pT reg cells in colitic mice partly through Sox12 induction.
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DOI：
10.1084/jem.20130791
发表时间：
2014-08-25
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Tanaka S;Suto A;Iwamoto T;Kashiwakuma D;Kagami S;Suzuki K;Takatori H;Tamachi T;Hirose K;Onodera A;Suzuki J;Ohara O;Yamashita M;Nakayama T;Nakajima H
通讯作者：
Nakajima H
DOI：
10.1016/j.biocel.2009.07.018
发表时间：
2010-03
影响因子：
4
作者：
Penzo-Mendez, Alfredo I.
通讯作者：
Penzo-Mendez, Alfredo I.
影响因子：
64.8
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Rosenblum, Michael D.;Gratz, Iris K.;Paw, Jonathan S.;Lee, Karen;Marshak-Rothstein, Ann;Abbas, Abul K.
通讯作者：
Abbas, Abul K.
病原体特异性的Treg细胞在结核分枝杆菌感染期间早期膨胀，但随后因白介素12而被消除。
影响因子：
32.4
作者：
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通讯作者：
Urdahl KB
白介素10在抑制肠炎的调节T细胞功能中的重要作用。
影响因子：
15.3
作者：
Asseman, C;Mauze, S;Leach, M W;Coffman, R L;Powrie, F
通讯作者：
Powrie, F