Ventromedial Nucleus of the Hypothalamus Neurons Under the Magnifying Glass.

Ventromedial Nucleus of the Hypothalamus Neurons Under the Magnifying Glass.
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DOI:
10.1210/endocr/bqab141
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发表时间:
2021-10-01
期刊:
影响因子:
4.8
通讯作者:
Luckman SM
Luckman SM
中科院分区:
医学2区
文献类型:
--
作者:
Khodai T;Luckman SM

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下丘脑腹内侧核(VMH)是一个复杂的大脑结构,与许多神经内分泌功能,包括葡萄糖调节,产热,食欲,社会和性行为是不可或缺的。因此,毫不奇怪,细胞核正在进行深入的研究,以破译这些不同作用的机制。遗传和研究工具的发展,例如类固醇生成因子-1表达神经元的靶向,使我们能够更仔细地研究VMH,它的连接以及它如何影响竞争行为。在目前的审查中,我们的目标是将最近的研究结果纳入文献,并考虑可以得出的结论。
The ventromedial nucleus of the hypothalamus (VMH) is a complex brain structure that is integral to many neuroendocrine functions, including glucose regulation, thermogenesis, and appetitive, social, and sexual behaviors. As such, it is of little surprise that the nucleus is under intensive investigation to decipher the mechanisms which underlie these diverse roles. Developments in genetic and investigative tools, for example the targeting of steroidogenic factor-1-expressing neurons, have allowed us to take a closer look at the VMH, its connections, and how it affects competing behaviors. In the current review, we aim to integrate recent findings into the literature and contemplate the conclusions that can be drawn.
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