Essential nontranslational functions of tRNA synthetases.
Essential nontranslational functions of tRNA synthetases.
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DOI：
10.1038/nchembio.1158
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发表时间：
2013-03
影响因子：
14.8
通讯作者：
Schimmel, Paul
中科院分区：
文献类型：
--
作者：
Guo, Min;Schimmel, Paul
脊椎动物氨酰tRNA合成酶（aaRSs）催化蛋白质合成所需的氨酰-tRNA的产生，其非翻译功能最近被发现。虽然这些新功能被认为是“兼职活动”，但许多功能对细胞内稳态的重要性与翻译活动一样。新的作用与细胞质形式以及细胞核和分泌的细胞外形式相关，这些形式影响心血管发育、免疫应答以及mTOR、IFN-γ和p53信号传导的途径。aaRS与自身免疫性疾病、癌症和神经系统疾病的关联进一步突出了这些蛋白质的非翻译功能。aaRSs的新结构阐述伴随着它们在高等生物中的功能扩展，并与几种aaRSs的非翻译功能相关。虽然对这些功能如何发展的一般理解是有限的，但aaRS用于基本非翻译功能的征用可能是通过将氨基酸结合位点用于另一目的而开始的。
Nontranslational functions of vertebrate aminoacyl tRNA synthetases (aaRSs), which catalyze the production of aminoacyl-tRNAs for protein synthesis, have recently been discovered. While these new functions were thought to be ‘moonlighting activities’, many are as critical for cellular homeostasis as the activity in translation. New roles have been associated with cytoplasmic forms as well as with nuclear and secreted extracellular forms that impact pathways for cardiovascular development, the immune response, and mTOR, IFN-γ and p53 signaling. The associations of aaRSs with autoimmune disorders, cancers and neurological disorders further highlight nontranslational functions of these proteins. Novel architecture elaborations of the aaRSs accompany their functional expansion in higher organisms and have been associated with the nontranslational functions for several aaRSs. While a general understanding of how these functions developed is limited, the expropriation of aaRSs for essential nontranslational functions may have been initiated by co-opting the amino acid binding site for another purpose.
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影响因子：
11.4
作者：
Beebe, K;de Pouplana, LR;Schimmel, P
通讯作者：
Schimmel, P
影响因子：
4.8
作者：
Francin, M;Kaminska, M;Mirande, M
通讯作者：
Mirande, M
影响因子：
11.4
作者：
CERINI, C;KERJAN, P;SEMERIVA, M
通讯作者：
SEMERIVA, M
影响因子：
4.7
作者：
Choi, Jin Woo;Um, Jung Yeon;Kim, Sunghoon
通讯作者：
Kim, Sunghoon
问家族蛋白在压力反应和疾病中的作用。
DOI：
10.1186/1478-811x-7-9
发表时间：
2009-04-24
期刊：
Cell communication and signaling : CCS
影响因子：
--
作者：
Hattori K;Naguro I;Runchel C;Ichijo H
通讯作者：
Ichijo H