Mitochondrial Dynamics in the Brain Are Associated With Feeding, Glucose Homeostasis, and Whole-Body Metabolism.
Mitochondrial Dynamics in the Brain Are Associated With Feeding, Glucose Homeostasis, and Whole-Body Metabolism.
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DOI：
10.3389/fendo.2020.580879
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发表时间：
2020
影响因子：
5.2
通讯作者：
Filippi BM
中科院分区：
文献类型：
--
作者：
Haigh JL;New LE;Filippi BM
大脑负责通过改变能量输入和可用性来维持全身能量稳态。下丘脑和背侧迷走神经复合体（DVC）是代谢控制的主要部位，能够感知激素和营养物质并相应地适应代谢。线粒体通过融合或分裂来响应营养物质的可用性水平，以维持能量稳态;然而，这些过程可能会被代谢疾病（包括肥胖症和II型糖尿病（T2 D））破坏。线粒体动力学在肥胖和T2 D的发展和维持中至关重要，在控制下丘脑和DVC中的神经元和神经胶质的葡萄糖稳态和全身代谢中发挥作用。
The brain is responsible for maintaining whole-body energy homeostasis by changing energy input and availability. The hypothalamus and dorsal vagal complex (DVC) are the primary sites of metabolic control, able to sense both hormones and nutrients and adapt metabolism accordingly. The mitochondria respond to the level of nutrient availability by fusion or fission to maintain energy homeostasis; however, these processes can be disrupted by metabolic diseases including obesity and type II diabetes (T2D). Mitochondrial dynamics are crucial in the development and maintenance of obesity and T2D, playing a role in the control of glucose homeostasis and whole-body metabolism across neurons and glia in the hypothalamus and DVC.
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