Chinese bone turnover marker study: reference ranges for C-terminal telopeptide of type I collagen and procollagen I N-terminal peptide by age and gender.
Chinese bone turnover marker study: reference ranges for C-terminal telopeptide of type I collagen and procollagen I N-terminal peptide by age and gender.
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中国骨转换标志物研究：I型胶原C端肽和I型原胶原N端肽的参考范围（按年龄和性别）
DOI：
10.1371/journal.pone.0103841
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Xu L
中科院分区：
文献类型：
--
作者：
Li M;Li Y;Deng W;Zhang Z;Deng Z;Hu Y;Xia W;Xu L
骨形成标志物I型胶原n末端肽（PINP）和I型胶原c末端末端肽（β-CTX）是骨质疏松症鉴别诊断和治疗评价的有用生物标志物，但需要参考值。这项多中心、横断面的中国骨转换标志物研究包括来自中国5个城市的3800名健康志愿者。化学发光法检测血清PINP、β-CTX、甲状旁腺激素（PTH）和25OHD水平。采用双能x线骨密度仪测量腰椎和股骨近端骨密度。根据年龄、性别、体重、招募纬度、PTH和25OHD水平评估血清PINP和β-CTX水平。受试者（n = 1436, M∶F, 500∶936，平均年龄50.6±19.6岁）的PINP和β-CTX表现出非正态分布，在15-19岁之间达到峰值，在整个成年期逐渐下降，绝经后10年内升高，到70岁时下降。在30岁至绝经期的女性中，PINP和β-CTX的中位水平分别为40.42 （95% CI: 17.10-102.15）和0.26 (95% CI: 0.08-0.72) ng/mL。β-CTX与PINP呈线性正相关（r = 0.599， P<0.001）。β-CTX与25OHD、PTH呈正相关（r = 0.054、0.093），PINP与PTH呈负相关（r = - 0.012、- 0.053）（P<0.05）。建立了PINP和CTX的中文参考范围。中国人血清PINP和β-CTX水平在15 ~ 19岁和绝经期较高，70岁后逐渐下降。
Bone formation marker procollagen I N-terminal peptide (PINP) and resorption marker C-terminal telopeptide of type I collagen (β-CTX) are useful biomarkers for differential diagnosis and therapeutic evaluation of osteoporosis, but reference values are required. The multi-center, cross-sectional Chinese Bone Turnover Marker Study included 3800 healthy volunteers in 5 Chinese cities. Serum PINP, β-CTX, parathyroid hormone (PTH) and 25OHD levels were measured by chemiluminescence assay. Lumbar spine and proximal femur BMD were measured by dual-energy X-ray absorptiometry. Serum PINP and β-CTX levels were assessed by age, gender, weight, recruitment latitude, levels of PTH and 25OHD. Subjects (n = 1436, M∶F, 500∶936; mean age 50.6±19.6 years) exhibited non-normally distributed PINP and β-CTX peaking between 15–19 years, gradually declining throughout adulthood, elevating within 10 years of postmenopause, and then declining by age 70. In women between the age of 30 and menopause, median PINP and β-CTX levels were 40.42 (95% CI: 17.10–102.15) and 0.26 (95% CI: 0.08–0.72) ng/mL, respectively. β-CTX and PINP were positively linearly correlated (r = 0.599, P<0.001). β-CTX correlated positively (r = 0.054 and 0.093) and PINP correlated negatively (r = −0.012 and −0.053) with 25OHD and PTH (P<0.05). We established Chinese reference ranges for PINP and CTX. Chinese individuals exhibited high serum PINP and β-CTX levels between 15 and 19 years of age and at menopause, which gradually declined after 70 years of age.
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6.2
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