Slug inhibits the proliferation and tumor formation of human cervical cancer cells by up-regulating the p21/p27 proteins and down-regulating the activity of the Wnt/β-catenin signaling pathway via the trans-suppression Akt1/p-Akt1 expression.
Slug inhibits the proliferation and tumor formation of human cervical cancer cells by up-regulating the p21/p27 proteins and down-regulating the activity of the Wnt/β-catenin signaling pathway via the trans-suppression Akt1/p-Akt1 expression.
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Slug 通过上调 p21/p27 蛋白并通过反式抑制 Akt1/p-Akt1 表达下调 Wnt/β-catenin 信号通路的活性来抑制人宫颈癌细胞的增殖和肿瘤形成
DOI：
10.18632/oncotarget.8434
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发表时间：
2016-05-03
期刊：
影响因子：
--
通讯作者：
Zheng PS
中科院分区：
文献类型：
--
作者：
Cui N;Yang WT;Zheng PS
Slug（Snai 2）已被证明在不同的人类癌症中作为癌基因或肿瘤抑制基因，但Slug在宫颈癌中的功能仍然知之甚少。在这项研究中，我们证明了Slug可以抑制体外宫颈癌细胞的增殖和体内肿瘤的形成。进一步的实验发现Slug可以通过与Akt 1基因启动子中的E-box基序结合，反式抑制Akt 1/p-Akt 1的表达，进而通过上调p21/p27和/或下调Wnt/β-catenin信号通路的活性，抑制宫颈癌细胞的细胞增殖和肿瘤形成。因此，Slug在宫颈癌发生过程中起着抑癌作用。
Slug (Snai2) has been demonstrated to act as an oncogene or tumor suppressor in different human cancers, but the function of Slug in cervical cancer remains poorly understood. In this study, we demonstrated that Slug could suppress the proliferation of cervical cancer cells in vitro and tumor formation in vivo. Further experiments found that Slug could trans-suppress the expression of Akt1/p-Akt1 by binding to E-box motifs in the promoter of the Akt1 gene and then inhibit the cell proliferation and tumor formation of cervical cancer cells by up-regulating p21/p27 and/or down-regulating the activity of the Wnt/β-catenin signaling pathway. Therefore, Slug acts as a tumor suppressor during cervical carcinogenesis.
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影响因子：
3.8
作者：
Haslehurst AM;Koti M;Dharsee M;Nuin P;Evans K;Geraci J;Childs T;Chen J;Li J;Weberpals J;Davey S;Squire J;Park PC;Feilotter H
通讯作者：
Feilotter H
DOI：
10.1073/pnas.060025397
发表时间：
2000-04-11
影响因子：
11.1
作者：
Lin, SY;Xia, WY;Hung, MC
通讯作者：
Hung, MC
影响因子：
4.8
作者：
Fukumoto, S;Hsieh, CM;Lee, ME
通讯作者：
Lee, ME
影响因子：
11.2
作者：
Chen, ZY;Wang, XS;Tseng, CC
通讯作者：
Tseng, CC
影响因子：
50.3
作者：
Inoue, A;Seidel, MG;Look, AT
通讯作者：
Look, AT