Highly effective thieno[2,3-b]indole-diketopyrrolopyrrole near-infrared photosensitizer for photodynamic/photothermal dual mode therapy
Highly effective thieno[2,3-b]indole-diketopyrrolopyrrole near-infrared photosensitizer for photodynamic/photothermal dual mode therapy
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用于光动力/光热双模式治疗的高效噻吩并[2,3-b]吲哚二酮吡咯并吡咯近红外光敏剂
DOI：
10.1016/j.dyepig.2017.08.023
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发表时间：
2017-12
影响因子：
4.5
通讯作者：
Dong X.
中科院分区：
文献类型：
--
作者：
Yang J.;Cai Y.;Zhou Y.;Zhang C.;Liang P.;Zhao B.;Shao J.;Fu N.;Huang W.;Dong X.
合成具有近红外吸收、光稳定性好、单线态氧产生效率高、光热转换效率高、生物相容性好的光动力和光热剂是光动力疗法(PDT)和光热疗法(PTT)应用的必要条件。设计合成了三种基于硫代并[2，3-b]吲哚(TI)和二酮基吡咯(DPP)的近红外吸收化合物。仔细测定了它们的UV-VIS-NIR吸收、光致发光、电子分布、能级和热致相变。作为结构类似物，只有DPP-TI具有优异的单线态氧量子产率(1O2，ΦΔ=48.5%)，表现出与水中纳米粒子一样的有效光热转化效率(η=915.8%)。初步探讨了DPP-TINO纳米微粒在体外仅用一个波长的光作为协同PDT和PTT的荧光成像治疗剂的潜力。
Synthesis of photodynamic and photothermal agents with absorption in the near-infrared (NIR) region and featuring excellent photostability, high singlet oxygen generation efficiency, good photothermal conversion efficiency, and good biocompatibility is necessary for the application of photodynamic therapy (PDT) and phtothermal therapy (PTT). Three NIR absorption compounds based on thieno[2,3-b]indole (TI) and diketopyrrolopyrrole (DPP) were designed and synthesized. Their UV-vis-NIR absorption, photoluminescence, electronic distribution, energy levels and thermally induced phase transitions have been carefully determined. As structural analogues, onlyDPP-TIpossesses excellent singlet oxygen quantum yield (1O2, ΦΔ= 48.5%), which displays effective photothermal conversion efficiency (η = 15.8%) as nanoparticles in water. The potential ofDPP-TInanoparticles as fluorescence imaging therapeutic agent for synergetic PDT and PTT in vitro using only one wavelength light were explored preliminarily.
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DOI：
10.1039/c6tb00709k
发表时间：
2016-08
期刊：
Journal of materials chemistry. B
影响因子：
--
作者：
Shuailiang Wang;Anyao Bi;Wenbin Zeng;Zhen Cheng
通讯作者：
Shuailiang Wang;Anyao Bi;Wenbin Zeng;Zhen Cheng
影响因子：
62.1
作者：
Singh S;Aggarwal A;Bhupathiraju NV;Arianna G;Tiwari K;Drain CM
通讯作者：
Drain CM
影响因子：
46.2
作者：
Kamkaew A;Lim SH;Lee HB;Kiew LV;Chung LY;Burgess K
通讯作者：
Burgess K
DOI：
10.1002/chin.200440261
发表时间：
2004-10
期刊：
ChemInform
影响因子：
--
作者：
M. Detty;S. Gibson;S. Wagner
通讯作者：
M. Detty;S. Gibson;S. Wagner
DOI：
10.1177/000134551006100403
发表时间：
1999-03
期刊：
Abstracts in Anthropology
影响因子：
--
作者：
D. Lit
通讯作者：
D. Lit