Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: a 13-year longitudinal study.
Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: a 13-year longitudinal study.
复制标题
DOI：
10.1038/mp.2014.95
复制
发表时间：
2014-10
影响因子：
11
通讯作者：
Barker, E. D.
中科院分区：
文献类型：
--
作者：
Cecil, C. A. M.;Lysenko, L. J.;Jaffee, S. R.;Pingault, J-B;Smith, R. G.;Relton, C. L.;Woodward, G.;McArdle, W.;Mill, J.;Barker, E. D.
具有高度冷酷无情特质(CU)的年轻人有早发性和持续性行为问题的风险。研究表明，CU可能有不同的发育途径(遗传/体质与环境)，而共生内化问题的缺乏或存在是一个关键标志。然而，目前还不清楚这种区别是否有效。中间表型，如DNA甲基化，一种调节基因表达的表观遗传修饰，可能有助于阐明病原学途径。这是第一项关于环境风险(产前/出生后)和DNA甲基化(出生，7岁，9岁)在预测CU(13岁)时的预期相互关系的研究，在青少年内化问题低与高的情况下。我们专注于催产素受体(OXTR)基因附近的DNA甲基化，因为它以前被认为与CU有关。参与者是84名早发性和持续性行为问题的青年，这些青年来自雅芳亲子纵向研究。对于低内化问题的青少年(46%)，我们发现：(I)出生时OXTR甲基化与较高的CU(13岁)以及较少的童年受害经历(出生-9岁)有关，(Ii)出生时较高的OXTR甲基化与较高的产前父母风险(母亲的精神病理、犯罪行为、药物使用)有关，以及(Iii)OXTR甲基化水平随着时间的推移更稳定(出生-9岁)。相反，对于有高度内化问题的青少年，CU与人际关系性质的产前风险(即亲密伴侣暴力、家庭冲突)有关，但与OXTR甲基化无关。研究结果支持CU存在不同的发育途径。
Youth with high callous-unemotional traits (CU) are at risk for early-onset and persistent conduct problems. Research suggests that there may be different developmental pathways to CU (genetic/constitutional vs environmental), and that the absence or presence of co-occurring internalizing problems is a key marker. However, it is unclear whether such a distinction is valid. Intermediate phenotypes such as DNA methylation, an epigenetic modification regulating gene expression, may help to clarify aetiological pathways. This is the first study to examine prospective inter-relationships between environmental risk (prenatal/postnatal) and DNA methylation (birth, age 7, age 9) in the prediction of CU (age 13), for youth low vs. high in internalizing problems. We focused on DNA methylation in the vicinity of the oxytocin receptor (OXTR) gene as it has been previously implicated in CU. Participants were 84 youth with early-onset and persistent conduct problems drawn from the Avon Longitudinal Study of Parents and Children. For youth with low internalizing problems (46%), we found that: (i) OXTR methylation at birth associated with higher CU (age 13) as well as decreased experience of victimization during childhood (birth – age 9), (ii) higher prenatal parental risks (maternal psychopathology, criminal behaviors, substance use) associated with higher OXTR methylation at birth, and (iii) OXTR methylation levels were more stable across time (birth – age 9). In contrast, for youth with high internalizing problems, CU was associated with prenatal risks of an interpersonal nature (i.e., intimate partner violence, family conflict) but not OXTR methylation. Findings support the existence of distinct developmental pathways to CU.
登录
查看更多内容
DOI：
10.1080/10705519909540118
发表时间：
1999-01-01
影响因子：
6
作者：
Hu, Li-tze;Bentler, Peter M.
通讯作者：
Bentler, Peter M.
影响因子：
16.2
作者：
Insel, Thomas R.
通讯作者：
Insel, Thomas R.
DOI：
10.1111/gbb.12085
发表时间：
2013-11
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Eicher JD;Powers NR;Miller LL;Akshoomoff N;Amaral DG;Bloss CS;Libiger O;Schork NJ;Darst BF;Casey BJ;Chang L;Ernst T;Frazier J;Kaufmann WE;Keating B;Kenet T;Kennedy D;Mostofsky S;Murray SS;Sowell ER;Bartsch H;Kuperman JM;Brown TT;Hagler DJ Jr;Dale AM;Jernigan TL;St Pourcain B;Davey Smith G;Ring SM;Gruen JR;Pediatric Imaging, Neurocognition, and Genetics Study
通讯作者：
Pediatric Imaging, Neurocognition, and Genetics Study
影响因子：
9.3
作者：
Gregory SG;Connelly JJ;Towers AJ;Johnson J;Biscocho D;Markunas CA;Lintas C;Abramson RK;Wright HH;Ellis P;Langford CF;Worley G;Delong GR;Murphy SK;Cuccaro ML;Persico A;Pericak-Vance MA
通讯作者：
Pericak-Vance MA
DOI：
10.1111/j.1469-7610.2012.02579.x
发表时间：
2012-11-01
影响因子：
7.6
作者：
Barker, Edward D.;Salekin, Randall T.
通讯作者：
Salekin, Randall T.