The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior.

The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior.
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DOI:
10.1016/j.neuron.2010.03.005
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发表时间:
2010-03-25
期刊:
影响因子:
16.2
通讯作者:
Insel, Thomas R.
Insel, Thomas R.
中科院分区:
医学1区
文献类型:
--
作者:
Insel, Thomas R.

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社会神经科学正在迅速探索感知和行动之间的复杂领域,其中识别,价值和意义被实例化。这篇评论遵循催产素和加压素的研究线索,作为探索社会神经科学“暗物质”的一条路径的范例。对脊椎动物物种的研究表明,这些神经肽对社会认知很重要,具有性别和类固醇依赖性。在田鼠的比较研究产生了一个模型的基础上,种间和种内变化的地理催产素受体和血管加压素V1a受体在前脑。高度亲和的物种在大脑回路中有与奖励或强化有关的受体。这些受体的神经解剖学分布可能由其各自基因的调节区域的变化来指导。这篇综述描述了将这些发现外推到人类社会认知的前景和问题,特别提到了自闭症的社会缺陷。
Social neuroscience is rapidly exploring the complex territory between perception and action where recognition, value, and meaning are instantiated. This review follows the trail of research on oxytocin and vasopressin as an exemplar of one path for exploring the “dark matter” of social neuroscience. Studies across vertebrate species suggest that these neuropeptides are important for social cognition, with gender and steroid-dependent effects. Comparative research in voles yields a model based on inter-species and intra-species variation of the geography of oxytocin receptors and vasopressin V1a receptors in the forebrain. Highly affiliative species have receptors in brain circuits related to reward or reinforcement. The neuroanatomical distribution of these receptors may be guided by variations in the regulatory regions of their respective genes. This review describes the promises and problems of extrapolating these findings to human social cognition, with specific reference to the social deficits of autism.
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