Association between asthma status and prenatal antibiotic prescription fills among women in a Medicaid population.
Association between asthma status and prenatal antibiotic prescription fills among women in a Medicaid population.
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DOI：
10.1080/02770903.2021.1993247
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发表时间：
2022-10
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影响因子：
--
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中科院分区：
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--
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患有哮喘的孕妇呼吸道病毒感染和病情加重的频率增加。由于这些风险，患有哮喘的女性在怀孕期间可能会受到更多的监测，因此可能会增加抗生素的使用风险。本研究的目的是评估母亲哮喘与门诊产前抗生素处方填充之间的关系，以告知抗生素管理。我们纳入了参加田纳西州医疗补助计划的单胎、足月、非低出生体重和其他健康婴儿的妇女。孕妇哮喘和产前抗生素填充确定从医疗保健遇到和门诊药房索赔。我们用改良泊松回归分析了母亲哮喘和产前抗生素填充之间的关系。我们的研究人群包括168354名孕妇，其中4%患有哮喘。与无哮喘的女性相比，患有哮喘的女性服用至少一种产前抗生素处方的风险增加（调整后的风险比[aRR] 1.27，95%置信区间[CI] 1.25-1.28），妊娠期间服用抗生素的次数增加（aRR 1.54，95% CI 1.51-1.57）。在那些填写了至少一个抗生素处方的人中，哮喘妇女的第一次产前抗生素处方填写时间更早，并且在怀孕期间填写至少一个疗程的广谱抗生素的可能性增加（与窄谱相比）。患有哮喘的孕妇比没有哮喘的孕妇有更多的门诊抗生素处方。这些研究结果强调，患有哮喘的孕妇在怀孕期间不成比例地服用更多的抗生素处方，提供了可能为抗生素管理提供信息的数据。
Pregnant women with asthma have increased frequency of respiratory viral infections and exacerbations. Because of these risks, women with asthma may be subject to increased surveillance during pregnancy and may, therefore, be at increased risk of antibiotic receipt. The objective of this study was to assess the relationship between maternal asthma and outpatient prenatal antibiotic prescription fills to inform antibiotic stewardship. We included women who delivered a singleton, term, non-low birthweight, and otherwise healthy infant enrolled in the Tennessee Medicaid Program. Maternal asthma and prenatal antibiotic fills were ascertained from healthcare encounters and outpatient pharmacy claims. We examined the association between maternal asthma and prenatal antibiotic fills using modified Poisson regression. Our study population included 168354 pregnant women, 4% of whom had asthma. Women with asthma had an increased risk of filling at least one prenatal antibiotic prescription (adjusted risk ratio [aRR] 1.27, 95% confidence interval [CI] 1.25–1.28) and had an increased number of fills during pregnancy (aRR 1.54, 95% CI 1.51–1.57) compared to women without asthma. Among those who filled at least one antibiotic prescription, women with asthma had earlier first prenatal antibiotic prescription fill and increased likelihood of filling at least one course of broad-spectrum antibiotics during pregnancy (versus narrow-spectrum). Pregnant women with asthma had more outpatient antibiotic prescription fills than pregnant women without asthma. These findings highlight that pregnant women with asthma disproportionately fill more antibiotic prescriptions during pregnancy, providing data that may inform antibiotic stewardship.
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DOI：
10.3390/ijerph110807993
发表时间：
2014-08-07
影响因子：
--
作者：
Martinez de Tejada B
通讯作者：
Martinez de Tejada B
影响因子：
120.7
作者：
Fleming-Dutra, Katherine E.;Hersh, Adam L.;Hicks, Lauri A.
通讯作者：
Hicks, Lauri A.
影响因子：
7.2
作者：
通讯作者：
--
影响因子：
11.8
作者：
Donovan, Brittney M.;Abreo, Andrew;Wu, Pingsheng
通讯作者：
Wu, Pingsheng
影响因子：
7.7
作者：
Miller, Jessica Eden;Wu, Chunsen;Burgner, David P.
通讯作者：
Burgner, David P.