Histone Deacetylases as Epigenetic Targets for Treating Parkinson's Disease.
Histone Deacetylases as Epigenetic Targets for Treating Parkinson's Disease.
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DOI：
10.3390/brainsci12050672
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发表时间：
2022-05-21
期刊：
影响因子：
3.3
通讯作者：
中科院分区：
文献类型：
--
作者：
帕金森病（PD）是一种慢性进行性神经退行性疾病，日益成为全球老年人健康和生活的威胁。虽然临床上有一些药物可用于治疗PD，但这些治疗只能缓解PD患者的症状，而不能完全治愈疾病。因此，探索其他潜在的机制，以开发更有效的治疗方法，可以改变PD的过程仍然是非常可取的。在过去的二十年里，组蛋白去乙酰化酶作为一类重要的表观遗传靶点，在药物发现中受到了广泛的关注。本文就组蛋白去乙酰化酶及其抑制剂在帕金森病研究中的应用作一综述。还讨论了与可以抑制或降解组蛋白脱乙酰酶以治疗PD的小分子相关的进一步前景。
Parkinson’s disease (PD) is a chronic progressive neurodegenerative disease that is increasingly becoming a global threat to the health and life of the elderly worldwide. Although there are some drugs clinically available for treating PD, these treatments can only alleviate the symptoms of PD patients but cannot completely cure the disease. Therefore, exploring other potential mechanisms to develop more effective treatments that can modify the course of PD is still highly desirable. Over the last two decades, histone deacetylases, as an important group of epigenetic targets, have attracted much attention in drug discovery. This review focused on the current knowledge about histone deacetylases involved in PD pathophysiology and their inhibitors used in PD studies. Further perspectives related to small molecules that can inhibit or degrade histone deacetylases to treat PD were also discussed.
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