Clinical Developmental Cardiology for Understanding Etiology of Congenital Heart Disease.
Clinical Developmental Cardiology for Understanding Etiology of Congenital Heart Disease.
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DOI：
10.3390/jcm11092381
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发表时间：
2022-04-24
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
先天性心脏病（CHD）是心血管系统发育异常所致，通常涉及发育中的心脏和血管的特定步骤或结构成分的缺陷。我们身体左右模式的确定是通过一系列步骤进行的，包括节点中可动纤毛产生的向左“节点流”以及仅在胚胎左侧表达的分子，最终激活左侧特异性形态发生的分子通路。这些步骤中的任何一个被破坏都可能导致左右模式缺陷或内脏异位综合征。至于流出道的发育，神经嵴细胞迁移到心脏流出道，并有助于形成流出道的隔膜，该隔膜将胚胎的单一动脉干分为主动脉和肺动脉干。神经嵴细胞与来自第二心脏区域的另一群心肌前体细胞之间的相互信号传导对于流出道发育的各个步骤至关重要。为了更好地理解先天性心脏病的病因，重要的是要考虑心血管系统复杂发育过程中每个步骤的异常会导致何种先天性心脏病。
Congenital heart diseases (CHD) result from abnormal development of the cardiovascular system and usually involve defects in specific steps or structural components of the developing heart and vessels. The determination of left–right patterning of our body proceeds by the steps involving the leftward “nodal flow” by motile cilia in the node and molecules that are expressed only on the left side of the embryo, eventually activating the molecular pathway for the left-side specific morphogenesis. Disruption of any of these steps may result in left–right patterning defects or heterotaxy syndrome. As for the outflow tract development, neural crest cells migrate into the cardiac outflow tract and contribute to form the septum of the outflow tract that divides the embryonic single truncus arteriosus into the aortic and the pulmonary trunk. Reciprocal signaling between neural crest cells and another population of myocardial precursor cells originated from the second heart field are essential for the steps of outflow tract development. To better understand the etiology of CHD, it is important to consider what kind of CHD is caused by abnormalities in each step during the complex development of the cardiovascular system.
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影响因子：
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作者：
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