Abnormally increased effective connectivity between parahippocampal gyrus and ventromedial prefrontal regions during emotion labeling in bipolar disorder.
Abnormally increased effective connectivity between parahippocampal gyrus and ventromedial prefrontal regions during emotion labeling in bipolar disorder.
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DOI：
10.1016/j.pscychresns.2009.04.015
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发表时间：
2009-12-30
影响因子：
2.3
通讯作者：
Phillips, Mary L.
中科院分区：
文献类型：
--
作者：
Almeida, Jorge R. C.;Mechelli, Andrea;Hassel, Stefanie;Versace, Amelia;Kupfer, David J.;Phillips, Mary L.
关键词：
情绪倾向和情绪失调是双相情感障碍（BD）的特征，但尚未有研究调查海马旁回和前额叶皮质区在腹内侧和背侧神经系统中对双相情感障碍进行情绪调节的有效连接。21例DSM-IV诊断为双相障碍，I型目前已缓解；25名年龄和性别匹配的健康对照（HC）。参与者进行了一个与事件相关的范式，观看温和的、强烈的快乐的和中性的面孔。我们采用动态因果模型（DCM）来确定BD和HC之间有效连通性的显著变化。采用贝叶斯模型选择法确定最佳模型。右侧海马旁回（PHG）和右侧膝下扣带回（sgCG）作为腹内侧神经系统的代表性区域。右背外侧前额叶皮层（DLPFC）区域作为背外侧神经系统的代表。BD中右侧PHG-sgCG有效连通性明显大于HC，反映了BD中PHG-sgCG信号传导比HC更快、更正向。sgCG-DLPFC有效连通性组间无差异。在双相障碍中，右侧PHG- sgcg对情绪刺激的有效连接异常增加，右侧PHG活动异常减少，提示腹内侧神经系统功能失调，涉及情绪的早期刺激评价、编码和自动调节，这可能是双相障碍情绪失调的病理生理功能神经机制。
Emotional liability and mood dysregulation characterize bipolar disorder (BD), yet no study has examined effective connectivity between parahippocampal gyrus and prefrontal cortical regions in ventromedial and dorsal/lateral neural systems subserving mood regulation in BD. Forty-six individuals (age range: 18–56 years); 21 with a DSM-IV diagnosis of BD, type I currently remitted; 25 age- and gender-matched healthy controls (HC). Participants performed an event-related paradigm, viewing mild and intense happy and neutral faces. We employed dynamic causal modeling (DCM) to identify significant alterations in effective connectivity between BD and HC. Bayes model selection was used to determine the best model. The right parahippocampal gyrus (PHG) and right subgenual cingulate gyrus (sgCG) were included as representative regions of the ventromedial neural system. The right dorsolateral prefrontal cortex (DLPFC) region was included as representative of the dorsal/lateral neural system. Right PHG-sgCG effective connectivity was significantly greater in BD than HC, reflecting more rapid, forward PHG-sgCG signaling in BD than HC. There was no between-group difference in sgCG-DLPFC effective connectivity. In BD, abnormally increased right PHG-sgCG effective connectivity and reduced right PHG activity to emotional stimuli suggest a dysfunctional ventromedial neural system implicated in early stimulus appraisal, encoding and automatic regulation of emotion, that may represent a pathophysiological functional neural mechanism for mood dysregulation in BD.
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