New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?
New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?
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DOI：
10.1038/nrm3382
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发表时间：
2012-06-22
期刊：
影响因子：
--
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中科院分区：
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基因组DNA紧凑成染色质对转录、复制和DNA修复等关键过程的调控具有深远的意义。核小体是染色质的重复构件，其组蛋白成分的组成各不相同。这是变异组蛋白和组蛋白氨基酸侧链翻译后修饰的结果。由此导致的核小体结构、稳定性和动力学的变化影响了核小体阵列向高阶结构的紧凑。越来越清楚的是，染色质结构并不像之前假设的那样均匀和规则。这意味着染色质结构也必须在特定生物功能的背景下看待。
The compaction of genomic DNA into chromatin has profound implications for the regulation of key processes such as transcription, replication and DNA repair. Nucleosomes, the repeating building blocks of chromatin, vary in the composition of their histone protein components. This is the result of the incorporation of variant histones and post-translational modifications of histone amino acid side chains. The resulting changes in nucleosome structure, stability and dynamics affect the compaction of nucleosomal arrays into higher-order structures. It is becoming clear that chromatin structures are not nearly as uniform and regular as previously assumed. This implies that chromatin structure must also be viewed in the context of specific biological functions.
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影响因子：
64.8
作者：
Clarkson, MJ;Wells, JRE;Tremethick, DJ
通讯作者：
Tremethick, DJ
影响因子：
2.9
作者：
Chang, Evelyn Y.;Ferreira, Helder;Somers, Joanna;Nusinow, Dmitri A.;Owen-Hughes, Tom;Narlikar, Geeta J.
通讯作者：
Narlikar, Geeta J.
DOI：
10.1139/o10-024
发表时间：
2011-02
期刊：
Biochemistry and cell biology = Biochimie et biologie cellulaire
影响因子：
--
作者：
Caterino TL;Hayes JJ
通讯作者：
Hayes JJ
影响因子：
11.4
作者：
Bao, YH;Konesky, K;Luger, K
通讯作者：
Luger, K
DOI：
10.1101/sqb.2004.69.227
发表时间：
2004-01-01
期刊：
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY
影响因子：
--
作者：
Chakravarthy, S;Bao, Y;Luger, K
通讯作者：
Luger, K