Steroid hormones, dietary nutrients, and temporal progression of neurogenesis.

Steroid hormones, dietary nutrients, and temporal progression of neurogenesis.
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类固醇激素、饮食营养和神经发生的时间进程。

DOI:
10.1016/j.cois.2020.10.008
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发表时间:
2021-03
影响因子:
5.3
通讯作者:
Siegrist SE
Siegrist SE
中科院分区:
农林科学2区
文献类型:
--
作者:
Sood C;Doyle SE;Siegrist SE

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神经祖细胞的时间模式是在发育过程中产生神经元多样性的一种进化保守策略,其中不同的因子依次表达。在果蝇胚胎中,调节神经干细胞(神经母细胞)时间模式的机制主要是细胞固有的。然而,胚胎发生后,神经母细胞的时间模式也依赖于外部线索,因为新孵化的幼虫在不同的自然环境中寻找营养和其他关键资源。我们回顾了目前对神经母细胞内在时间程序的理解,并讨论了神经母细胞外在线索如何与神经母细胞内在程序整合和协调,以控制产生的神经元的数量和类型。影响神经母细胞及其子细胞的时间模式以及神经发生终止的一个关键的外部因素是类固醇激素,蜕皮激素,一种已知的昆虫和节肢动物大规模发育转变的调节剂。最后,我们考虑了进化保护,并讨论了早期脊椎动物大脑发育中甲状腺激素信号传导的最新工作。
Temporal patterning of neural progenitors, in which different factors are sequentially expressed, is an evolutionarily conserved strategy for generating neuronal diversity during development. In the Drosophila embryo, mechanisms that mediate temporal patterning of neural stem cells (neuroblasts) are largely cell-intrinsic. However, after embryogenesis, neuroblast temporal patterning relies on extrinsic cues as well, as freshly hatched larvae seek out nutrients and other key resources in varying natural environments. We recap current understanding of neuroblast-intrinsic temporal programs and discuss how neuroblast extrinsic cues integrate and coordinate with neuroblast intrinsic programs to control numbers and types of neurons produced. One key emerging extrinsic factor that impacts temporal patterning of neuroblasts and their daughters as well as termination of neurogenesis is the steroid hormone, ecdysone, a known regulator of large-scale developmental transitions in insects and arthropods. Lastly, we consider evolutionary conservation and discuss recent work on thyroid hormone signaling in early vertebrate brain development.
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