Overproduction of Neurons Is Correlated with Enhanced Cortical Ensembles and Increased Perceptual Discrimination.
Overproduction of Neurons Is Correlated with Enhanced Cortical Ensembles and Increased Perceptual Discrimination.
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DOI：
10.1016/j.celrep.2017.09.040
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发表时间：
2017-10-10
期刊：
影响因子：
8.8
通讯作者：
Yuste R
中科院分区：
文献类型：
--
作者：
Fang WQ;Yuste R
大脑的神经元数量和密度差异很大，即使在同一物种的个体之间也是如此，但目前还不清楚这种差异是否会导致大脑功能或行为的差异。通过对子宫内神经元产生适度增强的小鼠模型的皮质活动进行成像，我们发现具有更多皮质神经元的动物也在初级视觉皮层中产生增强的功能相关性和更明显的神经元集合。值得注意的是，这些老鼠在视觉行为上也有更敏锐的方向辨别力。这些结果表明，神经元的数量与功能模块性和知觉辨别的视觉皮层。通过实验将神经元数量和行为的差异联系起来，我们的发现可以帮助解释个体和物种变异的进化和发展基础如何导致感知和认知能力的差异。Fang等人报道，与野生型小鼠相比，具有更多皮质神经元的小鼠也具有更多的神经元集合和改善的视觉辨别力。这些发现表明，神经元的产生与视觉皮层中的功能模块化和感知辨别有关。
Brains vary greatly in neuron number and density, even across individuals within the same species, yet it remains unclear if such variation leads to differences in brain function or behavior. By imaging cortical activity of a mouse model where neuronal production is moderately enhanced in utero, we find that animals with more cortical neurons also develop enhanced functional correlations and more distinct neuronal ensembles in primary visual cortex. Remarkably, these mice also have sharper orientation discrimination in their visual behavior. These results suggest that neuronal number is linked to functional modularity and perceptual discrimination of visual cortex. By experimentally linking differences in neuronal number and behavior, our findings could help explain how the evolutionary and developmental basis of individual and species variability may lead to differences in perceptual and cognitive capabilities. Fang et al. report that mice engineered to have more cortical neurons also have more neuronal ensembles and improved visual discrimination, compared to wild-type mice. These findings suggest that neuronal production is linked to functional modularity and perceptual discrimination in the visual cortex.
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影响因子：
5.3
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影响因子：
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作者：
Lee, Seung-Hee;Kwan, Alex C.;Zhang, Siyu;Phoumthipphavong, Victoria;Flannery, John G.;Masmanidis, Sotiris C.;Taniguchi, Hiroki;Huang, Z. Josh;Zhang, Feng;Boyden, Edward S.;Deisseroth, Karl;Dan, Yang
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影响因子：
64.8
作者：
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DOI：
10.1073/pnas.1010356107
发表时间：
2010-09-07
影响因子：
11.1
作者：
Collins, Christine E.;Airey, David C.;Kaas, Jon H.
通讯作者：
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