Shape and Biomechanical Characteristics of Human Red Blood Cells in Health and Disease.

Shape and Biomechanical Characteristics of Human Red Blood Cells in Health and Disease.
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DOI:
10.1557/mrs2010.571
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发表时间:
2010-05
期刊:
影响因子:
5
通讯作者:
Suresh S
Suresh S
中科院分区:
材料科学3区
文献类型:
--
作者:
Diez-Silva M;Dao M;Han J;Lim CT;Suresh S

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人红细胞的双凹形状和相应的变形能力是其生物学功能的基本特征。红细胞的这一特征可能受到遗传或获得性病理条件的严重影响。在这篇综述中,我们强调了新的动态体外检测,探讨各种遗传性血液疾病和寄生虫感染性疾病,导致破坏红细胞形态和力学。特别是,高通量微流体装置的最新进展使得可以分选/鉴定具有不同机械生物学特性的健康和病理人类RBC。
The biconcave shape and corresponding deformability of the human red blood cell (RBC) is an essential feature of its biological function. This feature of RBCs can be critically affected by genetic or acquired pathological conditions. In this review, we highlight new dynamic in vitro assays that explore various hereditary blood disorders and parasitic infectious diseases that cause disruption of RBC morphology and mechanics. In particular, recent advances in high-throughput microfluidic devices make it possible to sort/identify healthy and pathological human RBCs with different mechanobiological characteristics.
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