New cancer cases attributable to diet among adults aged 30–84 years in France in 2015
New cancer cases attributable to diet among adults aged 30–84 years in France in 2015
复制标题
2015年法国30-84岁成年人因饮食导致的新癌症病例
DOI：
10.1017/s0007114518002544
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发表时间：
2018
影响因子：
3.6
通讯作者：
I. Soerjomataram
中科院分区：
文献类型：
--
作者：
K. Shield;H. Freisling;M. Boutron‐Ruault;M. Touvier;Claire Marant Micallef;M. Jenab;V. Deschamps;C. Hill;P. Ferrari;I. Margaritis;F. Bray;I. Soerjomataram
摘要本研究旨在估计2015年法国30-84岁成年人中因饮食导致的新发癌症病例数量，其中存在令人信服或可能的因果关系证据，并且在二次分析中，存在至少有限但提示性的因果关系证据。假设10年的潜伏期，估计可归因于饮食的癌症病例。膳食摄入量数据来自2006年法国全国营养和健康调查。膳食摄入量的反事实情景是基于膳食指南。相应的风险关系估计值来自荟萃分析、队列研究和一项病例对照研究。癌症发病率数据来自法国癌症登记网络。在全国范围内，不良的饮食习惯导致16930例新发癌症病例，占所有新发癌症病例的5.4%。水果和膳食纤维摄入量低是造成这一负担的最大因素，分别造成4787和4389例新发癌症病例。如果将其扩展到饮食成分和癌症对，至少有有限但提示性的因果关系证据，则估计有36049例新发癌症病例，占所有新发癌症病例的11.6%，可归因于饮食。这些研究结果表明，不利的饮食习惯导致法国出现大量新的癌症病例;然而，由于饮食，包括通过肥胖等间接机制导致的癌症数量存在很大程度的不确定性，因此需要进行更多的研究以确定饮食如何影响癌症风险。
Abstract This study aimed to estimate the number of new cancer cases attributable to diet among adults aged 30–84 years in France in 2015, where convincing or probable evidence of a causal association exists, and, in a secondary analysis, where at least limited but suggestive evidence of a causal association exists. Cancer cases attributable to diet were estimated assuming a 10-year latency period. Dietary intake data were obtained from the 2006 French National Nutrition and Health Survey. Counterfactual scenarios of dietary intake were based on dietary guidelines. Corresponding risk relation estimates were obtained from meta-analyses, cohort studies and one case–control study. Cancer incidence data were obtained from the French Network of Cancer Registries. Nationally, unfavourable dietary habits led to 16 930 new cancer cases, representing 5·4 % of all new cancer cases. Low intake of fruit and dietary fibre was the largest contributor to this burden, being responsible for 4787 and 4389 new cancer cases, respectively. If this is expanded to dietary component and cancer pairs with at least limited but suggestive evidence of a causal association, 36 049 new cancer cases, representing 11·6 % of all new cancer cases, were estimated to be attributable to diet. These findings suggest that unfavourable dietary habits lead to a substantial number of new cancer cases in France; however, there is a large degree of uncertainty as to the number of cancers attributable to diet, including through indirect mechanisms such as obesity, and therefore additional research is needed to determine how diet affects cancer risk.
影响因子：
5
作者：
Ma, YS;Bertone, ER;Ockene, IS
通讯作者：
Ockene, IS
影响因子：
7.7
作者：
Schatzkin, A;Kipnis, V;Freedman, LS
通讯作者：
Freedman, LS