Loss of Gut Barrier Integrity In Lupus.
Loss of Gut Barrier Integrity In Lupus.
复制标题
狼疮中肠道屏障完整性的丧失。
DOI：
10.3389/fimmu.2022.919792
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发表时间：
2022
影响因子：
7.3
通讯作者：
Morel, Laurence
中科院分区：
文献类型：
--
作者：
Ma, Longhuan;Morel, Laurence
系统性红斑狼疮是一种复杂的自身免疫性疾病，其病因尚不清楚。据报道，狼疮患者的肠道通透性增加，但它是否促进或导致狼疮进展尚不清楚。最近的研究表明，受损的肠道屏障允许细菌和细菌成分易位到全身器官中，增加免疫细胞活化和自身抗体产生。事实上，在狼疮小鼠模型中诱导的肠漏增强了疾病特征，包括抗dsDNA抗体、血清IL-6以及细胞凋亡的产生。肠道微生物群生态失调已被认为是通过有害细菌及其产物的过度生长或通过肠道免疫稳态的扰动而降低肠道屏障完整性的因素之一，这反过来又影响肠道屏障完整性。微生物平衡的恢复消除了小鼠的肠道渗漏，进一步证实了微生物群在维持肠道屏障完整性方面的作用。在这篇综述中，我们讨论了微生物群生态失调和肠漏之间的关系，以及它们对狼疮进展的影响的最新进展。宿主微生物群和肠道完整性的改变可能为开发新的狼疮治疗提供见解。
Systemic Lupus Erythematosus is a complex autoimmune disease and its etiology remains unknown. Increased gut permeability has been reported in lupus patients, yet whether it promotes or results from lupus progression is unclear. Recent studies indicate that an impaired intestinal barrier allows the translocation of bacteria and bacterial components into systemic organs, increasing immune cell activation and autoantibody generation. Indeed, induced gut leakage in a mouse model of lupus enhanced disease characteristics, including the production of anti-dsDNA antibody, serum IL-6 as well as cell apoptosis. Gut microbiota dysbiosis has been suggested to be one of the factors that decreases gut barrier integrity by outgrowing harmful bacteria and their products, or by perturbation of gut immune homeostasis, which in turn affects gut barrier integrity. The restoration of microbial balance eliminates gut leakage in mice, further confirming the role of microbiota in maintaining gut barrier integrity. In this review, we discuss recent advances on the association between microbiota dysbiosis and leaky gut, as well as their influences on the progression of lupus. The modifications on host microbiota and gut integrity may offer insights into the development of new lupus treatment.
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