Plasma ghrelin concentrations change with physiological state in a sciurid hibernator (Spermophilus lateralis).
Plasma ghrelin concentrations change with physiological state in a sciurid hibernator (Spermophilus lateralis).
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DOI：
10.1016/j.ygcen.2009.12.006
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发表时间：
2010-04-01
影响因子：
2.7
通讯作者：
Florant, Gregory L.
中科院分区：
文献类型：
--
作者：
Healy, Jessica E.;Ostrom, Cara E.;Wilkerson, Gregory K.;Florant, Gregory L.
胃饥饿素是一种新发现的激素，对哺乳动物的食物摄入和脂肪生成有着深远的影响。在迄今为止研究的所有哺乳动物中，血浆胃饥饿素浓度在餐前升高，餐后立即下降；饥饿素水平随着禁食而增加。金毛地松鼠（也被称为侧胼胝体）是一种昼夜冬眠的动物，其体重的增加和减少主要由食物摄入控制。我们假设在春季、夏季和秋季，冬眠动物的内源性胃饥饿素浓度与非冬眠动物相似，但在冬季冬眠季节，血浆胃饥饿素浓度很低或检测不到。我们发现，6月份外周注射的胃饥饿素显著增加了食物摄入量。夏季短时禁食5 d后，血浆ghrelin浓度显著升高。在24小时内，胃饥饿素浓度在夜间上升，白天下降，与松鼠进食的时间相对应。在一月份，即使动物处于低体温（Tb），生长素浓度也很低，但仍可测量。此时胃饥饿素在血浆中持续存在的原因尚不清楚，但在冬眠动物体内循环的胃饥饿素可能与这些动物的睡眠控制有关。这是关于非光周期冬眠动物胃饥饿素浓度的首次报道。我们认为饥饿素可能对冬眠哺乳动物的食物摄入和体重周期的调节很重要。
Ghrelin is a recently discovered hormone which has profound effects on food intake and lipogenesis in mammals. In all mammals studied thus far, plasma ghrelin concentrations are increased before a meal and decrease immediately following a meal; ghrelin levels increase with fasting. The golden-mantled ground squirrel Spermophilus lateralis (also known as Callospermophilus lateralis (see)) is a diurnal hibernator which has a robust annual cycle of body mass gain and loss that is primarily controlled by food intake. We hypothesized that in spring, summer, and autumn, the endogenous ghrelin concentrations of hibernators would be similar to those of non-hibernators, but that during the winter hibernation season, plasma ghrelin concentrations would be low or undetectable. We found that peripherally injected ghrelin significantly increased food intake in June. Plasma ghrelin concentrations were significantly increased through 5 days of fasting during a short-term fast in summer. Over a 24 hour period, ghrelin concentrations increased at night and decreased during the day with drops corresponding to times when squirrels were eating. In January, ghrelin concentrations are low but measurable even while animals are at low body temperature (Tb). The reason for the persistence of ghrelin in plasma at this time is unclear, but circulating ghrelin in hibernators may be involved with the control of sleep in these animals. This is the first report of ghrelin concentrations in a non-photoperiodic hibernator. We suggest that ghrelin may be important for the regulation of food intake and the body mass cycle in mammals that hibernate.
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影响因子：
4.4
作者：
Deboer, T
通讯作者：
Deboer, T
DOI：
10.1152/ajpregu.00294.2004
发表时间：
2004-11-01
影响因子：
2.8
作者：
Bodosi, B;Gardi, J;Krueger, JM
通讯作者：
Krueger, JM
影响因子：
16.2
作者：
Cowley, MA;Smith, RG;Horvath, TL
通讯作者：
Horvath, TL
DOI：
10.1038/oby.2005.205
发表时间：
2005-10-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Kinzig, KP;Scott, KA;Moran, TH
通讯作者：
Moran, TH
DOI：
10.1139/z70-040
发表时间：
1970-01-01
期刊：
CANADIAN JOURNAL OF ZOOLOGY - BACK YEAR PROJECT
影响因子：
--
作者：
MROSOVSKY, N;FISHER, KC
通讯作者：
FISHER, KC