Volatile Organic Compound Assessment as a Screening Tool for Early Detection of Gastrointestinal Diseases.
Volatile Organic Compound Assessment as a Screening Tool for Early Detection of Gastrointestinal Diseases.
复制标题
DOI：
10.3390/microorganisms11071822
复制
发表时间：
2023-07-17
期刊：
影响因子：
4.5
通讯作者：
Markel, Troy A. A.
中科院分区：
文献类型：
--
作者：
Dalis, Costa;Mesfin, Fikir M. M.;Manohar, Krishna;Liu, Jianyun;Shelley, W. Christopher;Brokaw, John P. P.;Markel, Troy A. A.
胃肠道（GI）疾病在整个美国的患病率很高。筛查和诊断方式往往是昂贵和侵入性的，因此，人们不能有效地利用它们。缺乏适当的筛查和诊断评估可能导致诊断延迟，诊断时疾病更晚期，以及更高的发病率和死亡率。对肠道微生物组的研究表明，生态失调或有机体组成的不利改变先于各种胃肠道疾病的临床症状发作。胃肠道疾病诊断研究已经转向非侵入性胃肠道筛查方法，包括测量挥发性有机化合物（VOC）变化的化学检测测试，这些化合物是细菌代谢的副产品，导致粪便的独特气味。这些工具中的许多是昂贵的、固定的台式仪器，需要受过高度训练的个人来解释结果。这些属性使得它们难以在临床环境中实施。或者，电子鼻（E-nose）是相对便宜的手持设备，利用多传感器阵列和模式识别技术来分析VOC。本综述的目的是（1）强调生态失调如何影响肠道疾病以及如何利用VOC代谢物来检测微生物组的改变，（2）总结可用于检测肠道健康异常的VOC分析平台，（3）定义电子鼻技术的当前技术进步和局限性，最后，（4）回顾几种肠道疾病的相关文献，其中顶空VOCs可用于检测或预测疾病。
Gastrointestinal (GI) diseases have a high prevalence throughout the United States. Screening and diagnostic modalities are often expensive and invasive, and therefore, people do not utilize them effectively. Lack of proper screening and diagnostic assessment may lead to delays in diagnosis, more advanced disease at the time of diagnosis, and higher morbidity and mortality rates. Research on the intestinal microbiome has demonstrated that dysbiosis, or unfavorable alteration of organismal composition, precedes the onset of clinical symptoms for various GI diseases. GI disease diagnostic research has led to a shift towards non-invasive methods for GI screening, including chemical-detection tests that measure changes in volatile organic compounds (VOCs), which are the byproducts of bacterial metabolism that result in the distinct smell of stool. Many of these tools are expensive, immobile benchtop instruments that require highly trained individuals to interpret the results. These attributes make them difficult to implement in clinical settings. Alternatively, electronic noses (E-noses) are relatively cheaper, handheld devices that utilize multi-sensor arrays and pattern recognition technology to analyze VOCs. The purpose of this review is to (1) highlight how dysbiosis impacts intestinal diseases and how VOC metabolites can be utilized to detect alterations in the microbiome, (2) summarize the available VOC analytical platforms that can be used to detect aberrancies in intestinal health, (3) define the current technological advancements and limitations of E-nose technology, and finally, (4) review the literature surrounding several intestinal diseases in which headspace VOCs can be used to detect or predict disease.
登录
查看更多内容
影响因子：
5.2
作者：
通讯作者：
--
影响因子：
5.2
作者：
通讯作者：
--
影响因子：
3.7
作者：
Batty CA;Cauchi M;Lourenço C;Hunter JO;Turner C
通讯作者：
Turner C
影响因子：
4.9
作者：
Arasaradnam, Ramesh P.;Ouaret, Nathalie;Covington, James A.
通讯作者：
Covington, James A.
影响因子：
3.7
作者：
Arasaradnam RP;Westenbrink E;McFarlane MJ;Harbord R;Chambers S;O'Connell N;Bailey C;Nwokolo CU;Bardhan KD;Savage R;Covington JA
通讯作者：
Covington JA